Skeletal muscle fibers count on nuclear numbers for growth.
Skeletal muscle fibers count on nuclear numbers for growth.
复制标题
骨骼肌纤维的生长依赖于核数量。
DOI：
10.1016/j.semcdb.2021.04.015
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发表时间：
2021-11
影响因子：
7.3
通讯作者：
Millay, Douglas P.
中科院分区：
文献类型：
--
作者：
Prasad, Vikram;Millay, Douglas P.
骨骼肌细胞因其合胞体性质而值得注意，每个肌纤维积累数百或数千个来自常驻肌肉干细胞（MuSC）的细胞核。这些细胞核通过细胞融合积累，这是由两个基本的融合基因Myomaker和Myomerger控制的，它们在肌源性谱系中瞬时表达。虽然肌肉发育对融合的绝对要求已经知道了几十年，但肌肉中多核化的潜在需求仍然是神秘的。多核化的可能优势包括它在这些大细胞内提供转录多样性的潜力，以及作为增加DNA含量以支持最佳细胞大小和功能的手段。在这篇文章中，我们回顾了最近的进展，阐明肌纤维的数量和建立肌纤维的大小之间的关系，并讨论了这一新的信息如何完善我们的理解的概念肌纤维结构域（MND），细胞质体积，每个居民肌细胞核可以支持。最后，我们探讨了多核化的潜在后果和成本及其对肌细胞转录储备能力、生长潜力、肌纤维大小调节和肌肉适应性的影响。我们预计，这份报告不仅将突出合胞体肌细胞基础生物学的最新进展，还将提供信息，帮助设计下一代维持肌肉质量和功能的治疗策略。
Skeletal muscle cells are noteworthy for their syncytial nature, with each myofiber accumulating hundreds or thousands of nuclei derived from resident muscle stem cells (MuSCs). These nuclei are accrued through cell fusion, which is controlled by the two essential fusogens Myomaker and Myomerger that are transiently expressed within the myogenic lineage. While the absolute requirement of fusion for muscle development has been known for decades, the underlying need for the magnitude of multinucleation in muscle remains mysterious. Possible advantages of multinucleation include the potential it affords for transcriptional diversity within these massive cells, and as a means of increasing DNA content to support optimal cell size and function. In this article, we review recent advances that elucidate the relationship between myonuclear numbers and establishment of myofiber size, and discuss how this new information refines our understanding of the concept of myonuclear domains (MND), the cytoplasmic volumes that each resident myonucleus can support. Finally, we explore the potential consequences and costs of multinucleation and its impacts on myonuclear transcriptional reserve capacity, growth potential, myofiber size regulation, and muscle adaptability. We anticipate this report will not only serve to highlight the latest advances in the basic biology of syncytial muscle cells but also provide information to help design the next generation of therapeutic strategies to maintain muscle mass and function.
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影响因子：
5.5
作者：
Bruusgaard, JC;Liestol, K;Gundersen, K
通讯作者：
Gundersen, K
影响因子：
15.9
作者：
ASANO, Y;LIBERMAN, UA;EDELMAN, IS
通讯作者：
EDELMAN, IS
卫星细胞耗竭会破坏转录协调和肌肉适应运动。
DOI：
10.1093/function/zqaa033
发表时间：
2021
期刊：
Function (Oxford, England)
影响因子：
--
作者：
Englund DA;Figueiredo VC;Dungan CM;Murach KA;Peck BD;Petrosino JM;Brightwell CR;Dupont AM;Neal AC;Fry CS;Accornero F;McCarthy JJ;Peterson CA
通讯作者：
Peterson CA
影响因子：
16.6
作者：
Cramer AAW;Prasad V;Eftestøl E;Song T;Hansson KA;Dugdale HF;Sadayappan S;Ochala J;Gundersen K;Millay DP
通讯作者：
Millay DP
DOI：
10.1242/dev.167197
发表时间：
2018-10-25
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Bachman JF;Klose A;Liu W;Paris ND;Blanc RS;Schmalz M;Knapp E;Chakkalakal JV
通讯作者：
Chakkalakal JV