Thiamine deficiency in the bereaved after cancer-related spousal loss
Thiamine deficiency in the bereaved after cancer-related spousal loss
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癌症相关丧偶者家属缺乏硫胺素
DOI：
10.1017/s147895151900018x
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发表时间：
2019
影响因子：
2.2
通讯作者：
Ishida Mayumi
中科院分区：
文献类型：
--
作者：
Onishi Hideki;Uchida Nozomu;Takahashi Takao;Furuya Daisuke;Ebihara Yasuhiro;Sato Izumi;Ito Hiroshi;Ishida Mayumi
硫胺素缺乏症（TD）是公认的各种疾病与相关的食欲不振，包括癌症。然而，它还没有被确认到目前为止，在失去配偶后，从cancer.MethodFrom一系列失去配偶的合作伙伴谁失去了配偶的癌症，我们报告那些谁开发TD后丧亲之痛。ResultCase 1是一个57岁的女人谁寻求咨询，在我们的“丧亲之痛诊所”。她的丈夫一年前被诊断出患有胰腺癌，一个月前去世。在第一次就诊时，观察到她患有抑郁症、焦虑症和食欲下降。神经系统、血液和生化检查未发现任何值得注意的结果。她被诊断为单纯的丧亲之痛。详细检查显示，她的食欲明显下降约五周。TD的诊断是由她异常低的血清硫胺素水平支持的。病例2是一位73岁的丧妻男性，他的妻子在患病五年后于一个月前死于下咽癌。在他妻子去世前的一个月里，他表现出缺乏活力，但因为在她去世后没有改善，他的家人建议他到我们的“丧亲诊所”寻求咨询。他患有严重的抑郁症。详细的检查显示，他的食欲已经下降了两个多星期。再次，TD的诊断是由他的血清硫胺素水平异常低的支持。结果的意义这些报告表明，有一种可能性，丧亲之痛可能会发展TD后失去亲人。如病人食欲不振超过两星期，便应考虑是否患有TD，而医护人员亦应密切留意死者的身体状况，以防TD引致并发症。
ObjectiveThiamine deficiency (TD) is recognized in various kinds of disease with associated loss of appetite including cancer. However, it has not been recognized to date in bereaved partners after spousal loss from cancer.MethodFrom a series of bereaved partners who lost a spouse to cancer, we report on those who developed TD after bereavement.ResultCase 1 was a 57-year-old woman who sought consultation at our “bereavement clinic.” Her husband had been diagnosed with pancreatic cancer one year earlier and had died one month previously. At the first visit, she was observed to suffer depression, anxiety, and decreased appetite. Neurological, blood, and biochemical examinations did not reveal any noteworthy findings. She was diagnosed with uncomplicated bereavement. Detailed examination revealed that her appetite had been markedly decreased for approximately five weeks. The diagnosis of TD was supported by her abnormally low serum thiamine level. Case 2 was a bereaved 73-year-old male who had lost his wife to hypopharyngeal cancer one month previously after a five-year illness. He had shown a lack of energy for the month preceding his wife's death, but because there was no improvement after her death, his family recommended he seek consultation at our “bereavement clinic.” He was suffering from major depressive disorder. Detailed examination revealed that his appetite had been decreased for more than two weeks. Again, the diagnosis of TD was supported by his abnormally low serum thiamine level.Significance of resultsThese reports demonstrate that there is a possibility that bereaved could develop TD after the loss of a loved one. TD should be considered whenever there is a loss of appetite lasting for more than 2 weeks, and medical staff should pay careful attention to the physical condition of the bereaved to prevent complications because of TD.