Clear cell papillary renal cell carcinoma: Incidence, morphological features, immunohistochemical profile, and biologic behavior: A single institution study
Clear cell papillary renal cell carcinoma: Incidence, morphological features, immunohistochemical profile, and biologic behavior: A single institution study
复制标题
DOI：
10.1016/j.prp.2013.12.009
复制
发表时间：
2014-01-01
影响因子：
2.8
通讯作者：
Drachenberg, Cinthia B.
中科院分区：
文献类型：
--
作者：
Alexiev, Borislav A.;Drachenberg, Cinthia B.
本研究的目的是确定根据当前定义符合透明细胞乳头状肾细胞癌 (CCPRCC) 的肿瘤的发病率和临床病理特征。 2003年1月1日至2013年4月30日，共查明CCPRCC 28个（28/648，4.3%）。 CCPRCC 显示出不同的结构模式，包括囊状、乳头状、管状和腺泡状。无论结构如何，肿瘤均由立方形或柱状细胞组成，细胞质透明，细胞核小，呈圆形或椭圆形，核仁不明显。不同厚度的平滑肌肌动蛋白阳性软组织束包围整个肿瘤，形成连续的假包膜。 CCPRCC 强烈表达 PAX8、CA-IX、CK7、细胞角蛋白 34betaE12 和波形蛋白，并且 RCC、P504s/AMACR 和 TFE3 呈阴性。超微结构检查显示，CCPRCC 显示短微绒毛、细胞质交叉、核假包涵体和基质肌成纤维细胞。据我们所知，这是文献中首次对 CCPRCC 进行全面的超微结构研究。主要的鉴别诊断考虑是透明细胞肾细胞癌、多房性囊性肾细胞癌、伴有透明细胞改变的乳头状肾细胞癌和Xp11.2易位肾细胞癌。 CCPRCC 的预后似乎良好。在当前的系列中，没有患者出现局部复发或转移性疾病。 (C) 2014 年爱思唯尔有限公司。版权所有。
This study was undertaken to determine the incidence and the clinicopathologic characteristics of those tumors that qualify as clear cell papillary renal cell carcinoma (CCPRCC) by the current definitions. From January 1, 2003 to April 30, 2013, a total of twenty-eight CCPRCC were identified (28/648, 4.3%). CCPRCC showed variable architectural patterns including cystic, papillary, tubular, and acinar. Irrespective of the architecture, the tumors were composed of cuboidal or columnar cells with clear cytoplasm, small vesicular, round or oval nuclei, and inconspicuous nucleoli. Variably thick bundles of smooth muscle actin-positive soft tissue encircled the whole tumors, forming a continuous pseudocapsule. CCPRCC strongly expressed PAX8, CA-IX, CK7, cytokeratin 34betaE12, and vimentin, and were negative for RCC, P504s/AMACR, and TFE3. On ultrastructural examination, CCPRCC showed short microvilli, cytoplasmic interdigitations, nuclear pseudoinclusions, and stromal myofibroblasts. To the best of our knowledge, this is first comprehensive ultrastructural study of CCPRCC in the literature. The major differential diagnostic considerations are clear cell renal cell carcinoma, multilocular cystic renal cell carcinoma, papillary renal cell carcinoma with clear cell changes, and Xp11.2 translocation renal cell carcinoma. CCPRCC seems to have a favorable prognosis. In the current series, none of the patients had local recurrence or metastatic disease. (C) 2014 Elsevier GmbH. All rights reserved.