Alarmones as Vestiges of a Bygone RNA World
Alarmones as Vestiges of a Bygone RNA World
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DOI：
10.1007/s00239-018-9883-3
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发表时间：
2019-01-01
影响因子：
3.9
通讯作者：
Lazcano, Antonio
中科院分区：
文献类型：
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作者：
Hernandez-Morales, Ricardo;Becerra, Arturo;Lazcano, Antonio
所有已知的报警素都是核糖核苷酸或核糖核苷酸衍生物，它们在细胞处于应激条件下时合成，引发严格的反应，影响复制、基因表达和代谢等主要过程。警报素（例如 cAMP、Ap(n)A、cGMP、AICAR 和 ZTP）的丰富系统发育分布表明它们是非常古老的分子，可能在古细菌、细菌和真核生物领域进化分化之前就已经存在于细胞系统中。它们的化学结构、广泛的生物分布以及在高度保守的细胞过程中的功能作用支持了这样一种可能性：这些修饰的核苷酸是化学信号和代谢物传感进化时代的分子化石，在此期间，RNA分子在生物催化和遗传信息中发挥了更加显着的作用。
All known alarmones are ribonucleotides or ribonucleotide derivatives that are synthesized when cells are under stress conditions, triggering a stringent response that affects major processes such as replication, gene expression, and metabolism. The ample phylogenetic distribution of alarmones (e.g., cAMP, Ap(n)A, cGMP, AICAR, and ZTP) suggests that they are very ancient molecules that may have already been present in cellular systems prior to the evolutionary divergence of the Archaea, Bacteria, and Eukarya domains. Their chemical structure, wide biological distribution, and functional role in highly conserved cellular processes support the possibility that these modified nucleotides are molecular fossils of an epoch in the evolution of chemical signaling and metabolite sensing during which RNA molecules played a much more conspicuous role in biological catalysis and genetic information.