Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice.
Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice.
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Ljungan 病毒感染小鼠的宫内死亡、胎儿畸形和延迟妊娠。
DOI：
10.1002/bdrb.20083
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Niklasson,Bo
中科院分区：
文献类型：
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作者：
Samsioe,Annika;Feinstein,Ricardo;Saade,George;Sjoholm,Ake;Hornfeldt,Birger;Fundele,Reinald;Klitz,William;Niklasson,Bo
背景：微小核糖核酸病毒(LJunganVirus[LV])最近在其天然啮齿动物储藏室和人类中与妊娠期间的疾病有关。方法：CD-1雌性小鼠在妊娠第2天被感染，并受到不同形式的应激。结果：LV感染合并应激可导致子宫吸收、畸形和新生儿死亡。首次妊娠和分娩的时间有较短的延迟。结论：在欧美不同物种的本地动物中都发现了LV，人类流行病学证据表明LV与人类生殖有关，而这里的观察表明LV是导致实验室小鼠模型生殖问题的原因。目前的发现表明，LV也会导致孕妇及其后代患病的假设值得进一步研究。©2006 Wiley-Liss，Inc.
BACKGROUND:A picornavirus (Ljunganvirus [LV]) has recently been associated with disease during pregnancy in its natural rodent reservoir and in humans. A study of laboratory mice infected under controlled conditions was therefore undertaken.METHODS:CD‐1 female mice were infected gestational day two and subjected to varying regimes of stress.RESULTS:LV infection in combination with stress resulted in uterine resorptions, malformations, and neonatal death. A short delay in time to first pregnancy and births was observed in pairs infected in utero.CONCLUSIONS:LV is found in different species of native animals in both Europe and the United States and human epidemiological evidence connects LV and human reproduction, while the observations here indicate that LV is responsible for reproductive problems in a laboratory mouse model. The current findings suggest that the hypothesis that LV also causes disease in pregnant women and their offspring deserves further study.Birth Defects Res (Part B)77, 2006. © 2006 Wiley‐Liss, Inc.