Clinical, Serological, and Molecular Observations from a Case Series Study during the Asian Lineage Zika Virus Outbreak in Grenada during 2016
Clinical, Serological, and Molecular Observations from a Case Series Study during the Asian Lineage Zika Virus Outbreak in Grenada during 2016
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DOI：
10.1155/2018/4635647
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发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Macpherson, Calum N. L.
中科院分区：
文献类型：
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作者：
Brenciaglia, Marco;Noel, Trevor P.;Macpherson, Calum N. L.
本文介绍了2016年格林纳达寨卡病毒（Zika virus， ZIKV）暴发期间病例的时空分布、患者的人口统计学特征和临床表现。第一例报告病例于4月在圣安德鲁教区记录，最后一例报告病例于11月出现，根据检测结果，高峰传播发生在6月的最后一周。从总共514名患者中收集了数据，其中207名（40%）寨卡病毒检测呈阳性。没有证据表明寨卡病毒感染检测呈阳性与年龄、性别或妊娠状况有关。临床表现为皮疹（OR）。2.4, 95% ci。1.5至3.7)或淋巴结病（or）。1.7, 95% ci。1.0至2.9)是唯一与寨卡病毒感染检测呈阳性相一致的报告症状。在寨卡疫情期间，感染率为每1万人中有20例临床病例，而2014年格林纳达基孔肯雅疫情期间为每1万人中有41例，2001-2002年登革热疫情期间为每1万人中有17例。尽管该国实施了病媒控制规划，但感染率没有明显下降，但似乎需要新的减少方法，以尽量减少未来虫媒病毒暴发的发病率。
This paper describes the spatial and temporal distribution of cases, demographic characteristics of patients, and clinical manifestations of Zika virus (ZIKV) during the 2016 outbreak in Grenada. The first reported case was recorded in St. Andrew Parish in April, and the last reported case was seen in November, with peak transmission occurring in the last week of June, based on test results. Data were collected from a total of 514 patients, of whom 207 (40%) tested positive for ZIKV. No evidence was found that testing positive for ZIKV infection was related to age, gender, or pregnancy status. Clinical presentation with rash (OR. 2.4, 95% CI. 1.5 to 3.7) or with lymphadenopathy (OR. 1.7, 95% CI. 1.0 to 2.9) were the only reported symptoms consistent with testing positive for ZIKV infection. During the Zika outbreak, the infection rate was 20 clinical cases per 10,000 in the population compared to 41 cases per 10,000 during the chikungunya outbreak in Grenada in 2014 and 17 cases per 10,000 during the dengue outbreak in 2001-2002. Even though the country has employed vector control programs, with no apparent decrease in infection rates, it appears that new abatement approaches are needed to minimize morbidity in future arbovirus outbreaks.