T2′ imaging indicates decreased tissue metabolism in frontal white matter of MS patients
T2′ imaging indicates decreased tissue metabolism in frontal white matter of MS patients
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DOI：
10.1177/1352458509103713
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发表时间：
2009-06-01
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影响因子：
--
通讯作者：
Fiehler, J.
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文献类型：
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作者：
Holst, B.;Siemonsen, S.;Fiehler, J.
背景和目的T2 '-磁共振成像（MRI）可以评估正常出现的白色和灰质（NAWM和NAGM）的氧代谢，并对局部铁沉积敏感。我们假设，T2'成像是可行的，在常规使用，并揭示MS患者和健康subjects.Methods之间的差异T2和T2* 加权图像采集在23例MS患者（平均年龄：36.8，范围：23-58岁）和23名年龄匹配的健康受试者。结果MS患者丘脑和尾状核的T2 '值明显低于正常对照组（139 ms比157 ms，P < 0.001; 97 ms比115 ms，P < 0.01）;额叶NAWM的T2'值显著高于正常对照组（217 ms比170 ms，P < 0.001）。皮质下NAWM的T2'值显著低于正常对照组（174 ms vs 187 ms，P < 0.028）。基底神经节T2'值的降低可能与较高的铁浓度有关，而额叶NAWM T2'值的增加很可能反映了组织代谢的降低。T2'成像是可行的常规使用和有前途的监测治疗效果。多发性硬化2009; 15：701-707。http://msj.sagepub.com
Background and purpose T2'-Magnetic resonance imaging (MRI) allows estimation of oxygen metabolism in normal appearing white and gray matter (NAWM and NAGM) and is sensitive to local iron deposition. We hypothesized that T2' imaging is feasible in routine use and reveals differences between MS patients and healthy subjects.Methods T2- and T2*-weighted images were acquired in 23 MS patients (Mean age: 36.8, range: 23-58 years) and 23 age-matched healthy subjects. Quantitative T2- and T2*-values were determined in six regions of interest (ROIs).Results The T2' values in thalamus and caudate nucleus were significantly lower in MS patients than in healthy subjects (139 ms vs 157 ms, P < 0.001 and 97 ms vs 115 ms, P < 0.01). The NAWM in the frontal lobe revealed significant higher T2' values than in healthy subjects (217 ms vs 170 ms, P < 0.001). The subcortical NAWM revealed significant lower T2' values than in healthy subjects (174 ms vs 187 ms, P < 0.028).Conclusion T2' values differed significantly between MS patients and healthy subjects. The reduced T2' values in the basal ganglia are presumably related to higher iron concentration whereas the increased T2' in frontal NAWM most probably reflects reduced tissue metabolism. T2' imaging is feasible for routine-use and promising for monitoring therapy effects. Multiple Sclerosis 2009; 15: 701-707. http://msj.sagepub.com