The functional diversity of retinal ganglion cells in the mouse.
The functional diversity of retinal ganglion cells in the mouse.
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DOI：
10.1038/nature16468
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发表时间：
2016-01-21
期刊：
影响因子：
64.8
通讯作者：
Euler T
中科院分区：
文献类型：
--
作者：
Baden T;Berens P;Franke K;Román Rosón M;Bethge M;Euler T
在脊椎动物的视觉系统中，视网膜的所有输出均由视网膜神经节细胞携带。每种类型并行编码不同的视觉特征以传输到大脑。存在多少个这样的“输出通道”以及每个通道编码的内容是一个激烈争论的领域。在小鼠中，解剖学估计范围在 15-20 个通道之间，并且只有少数通道在功能上被了解。结合双光子钙成像来获得密集的视网膜记录和对超过 11,000 个细胞的所得样本进行无监督聚类，我们在此表明小鼠视网膜拥有超过 30 个功能输出通道。这些包括所有已知的和几种新的神经节细胞类型，经遗传和解剖标准验证。因此，从小鼠眼睛到小鼠大脑的信息通道比迄今为止解剖学研究显示的信息通道要多样化得多，这表明编码策略类似于最先进的人工视觉系统中使用的编码策略。
In the vertebrate visual system, all output of the retina is carried by retinal ganglion cells. Each type encodes distinct visual features in parallel for transmission to the brain. How many such “output channels” exist and what each encodes is an area of intense debate. In mouse, anatomical estimates range between 15–20 channels, and only a handful are functionally understood. Combining two-photon calcium imaging to obtain dense retinal recordings and unsupervised clustering of the resulting sample of >11,000 cells, we here show that the mouse retina harbours substantially more than 30 functional output channels. These include all known and several new ganglion cell types, as verified by genetic and anatomical criteria. Therefore, information channels from the mouse’s eye to the mouse’s brain are considerably more diverse than shown thus far by anatomical studies, suggesting an encoding strategy resembling that used in state-of-the-art artificial vision systems.