Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease.
Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease.
复制标题
DOI：
10.15252/emmm.201606540
复制
发表时间：
2016-10
影响因子：
11.1
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Mattsson N;Insel PS;Palmqvist S;Portelius E;Zetterberg H;Weiner M;Blennow K;Hansson O;Alzheimer's Disease Neuroimaging Initiative
脑脊液（CSF）tau（总tau，T-tau）、神经丝轻蛋白（NFL）和神经颗粒蛋白（Ng）是阿尔茨海默病（AD）神经变性的潜在生物标志物。尚不清楚这些生物标志物是否在AD中提供相似或互补的信息。我们检查了93例AD患者，187例轻度认知障碍患者和109例对照。T-tau、Ng和NFL都是AD诊断的预测因子。与单个生物标志物（T-tau 80.8%; Ng 71.4%; NFL 77.7%）相比，组合提高了诊断准确性（T-tau、Ng和NFL的AUC 85.5%）。T-tau和Ng高度相关（ρ = 0.79，P < 0.001），与β淀粉样蛋白（Aβ）病理学密切相关，并与认知和脑结构的纵向恶化密切相关，主要是在Aβ病理学患者中。另一方面，NFL与Aβ病理学无关，与独立于Aβ的认知能力下降和脑萎缩相关。T-tau、Ng和NFL提供了关于神经元损伤的部分独立信息，可以结合起来提高AD的诊断准确性。T-tau和Ng反映了Aβ依赖性神经变性，而NFL反映了独立于Aβ病理的神经变性。
Cerebrospinal fluid (CSF) tau (total tau, T‐tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T‐tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T‐tau, Ng, and NFL) compared to individual biomarkers (T‐tau 80.8%; Ng 71.4%; NFL 77.7%). T‐tau and Ng were highly correlated (ρ = 0.79, P < 0.001) and strongly associated with β‐amyloid (Aβ) pathology, and with longitudinal deterioration in cognition and brain structure, primarily in people with Aβ pathology. NFL on the other hand was not associated with Aβ pathology and was associated with cognitive decline and brain atrophy independent of Aβ. T‐tau, Ng, and NFL provide partly independent information about neuronal injury and may be combined to improve the diagnostic accuracy for AD. T‐tau and Ng reflect Aβ‐dependent neurodegeneration, while NFL reflects neurodegeneration independently of Aβ pathology.