Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation
Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation
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DOI：
10.1309/292nhaynwavrej37
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发表时间：
2003-07-01
影响因子：
3.5
通讯作者：
Li, M
中科院分区：
文献类型：
--
作者：
Fong, A;Garcia, E;Li, M
我们采用免疫组化方法检测了94例膀胱尿路上皮癌（UC）中Caveolin（Cav）-1和Cav-2的表达。22例良性尿路上皮瘤和10例扁平原位癌均未见Cav-1或Cav-2表达。94例UC中35例（37%）和89例UC中45例（51%）分别为Cav-1和Cav-2阳性。Cav-1在1级、2级和3级肿瘤中的阳性率分别为0%（016）、0%（0125）和56%（35163）（P <0.001），Cav-2分别为0%（016）、13%（3123）和70%（42160）（P <0.001）。
We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. Thirty-five (37%) of 94 cases and 45 (51%) of 89 cases of UC stained positively for Cav-1 and Cav-2, respectively. The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0% (016), 0% (0125), and 56% (35163), respectively (P < .001), and for Cav-2, 0% (016), 13% (3123), and 70% (42160), respectively (P