The Protective Effect of a Newly Developed Molecular Chaperone-Inducer Against Mouse Ischemic Acute Kidney Injury
The Protective Effect of a Newly Developed Molecular Chaperone-Inducer Against Mouse Ischemic Acute Kidney Injury
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DOI：
10.1254/jphs.08272sc
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发表时间：
2009-02-01
影响因子：
3.5
通讯作者：
Ikeda, Masahiro
中科院分区：
文献类型：
--
作者：
Prachasilchai, Worapat;Sonoda, Hlroko;Ikeda, Masahiro
未折叠蛋白反应（UPR）的激活被认为可以减轻肾缺血再灌注（I/R）损伤。我们最近发现了一种化合物，即 BIX，它可以通过激活转录因子 6 途径选择性激活 UPR。本研究检验了 BIX 对小鼠肾缺血再灌注损伤的影响。 BIX 选择性上调肾脏 BIP mRNA 和蛋白质。 BIX 预处理显着改善肾 I/R 损伤。 BIX 和衣霉素（一种非选择性 UPR 诱导剂）的共同给药没有提供额外的保护。我们的结果表明，BIX 激活 UPR 可以产生一种针对肾 I/R 损伤的新型药物疗法。
Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BIP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.