Increases in Body Mass Index Following Initiation of Methadone Treatment
Increases in Body Mass Index Following Initiation of Methadone Treatment
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DOI：
10.1016/j.jsat.2014.10.007
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发表时间：
2015-04-01
影响因子：
3.9
通讯作者：
Sigmon, Stacey C.
中科院分区：
文献类型：
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作者：
Fenn, Jennifer M.;Laurent, Jennifer S.;Sigmon, Stacey C.
尽管美沙酮对阿片类药物依赖有明显的疗效，但与美沙酮相关的一个不太理想的现象可能是体重增加。我们检查了接受美沙酮治疗的患者身体质量指数（BMI）的变化。对96例在美沙酮门诊就诊6个月的患者进行回顾性图表分析。BMI的主要结果在摄入时进行评估，并在大约1.8 +/- 0.95年后进行随后的体格检查。还检查了人口统计学、药物使用和治疗特征。摄入后BMI显著增加（p < 0.001）。平均bmi从27.2 +/- 6.8增加到30.1 +/- 7.7 kg/m(2)，在整个患者样本中转化为17.8磅的增加（体重增加10%）。性别是BMI变化的最强预测因子（p < 0.001），女性的BMI增幅明显大于男性（分别为5.2和1.7 kg/m）。这意味着女性体重增加了28磅（17.5%），而男性体重增加了12磅（6.4%）。总之，美沙酮治疗的入组与临床显著的体重增加有关，尤其是女性患者。这项研究强调了努力帮助患者减轻治疗期间体重增加的重要性，特别是考虑到肥胖对个人和社会的重大健康和经济后果。(C) 2015爱思唯尔公司版权所有。
Despite the clear efficacy of methadone for opioid dependence, one less desirable phenomenon associated with methadone may be weight gain. We examined changes in body mass index (BMI) among patients entering methadone treatment. A retrospective chart review was conducted for 96 patients enrolled in an outpatient methadone clinic for >= 6 months. The primary outcome of BMI was assessed at intake and a subsequent physical examination approximately 1.8 +/- 0.95 years later. Demographic, drug use and treatment characteristics were also examined. There was a significant increase in BMI following intake (p < 0.001). Mean BMIs increased from 27.2 +/- 6.8 to 30.1 +/- 7.7 kg/m(2), translating to a 17.8-pound increase (10% increase in body weight) in the overall patient sample. Gender was the strongest predictor of BMI changes (p < 0.001), with significantly greater BMI increases in females than males (5.2 vs. 1.7 kg/m(2), respectively). This translates to a 28-pound (17.5%) increase in females vs. a 12-pound (6.4%) increase in males. In summary, methadone treatment enrollment was associated with clinically significant weight gain, particularly among female patients. This study highlights the importance of efforts to help patients mitigate weight gain during treatment, particularly considering the significant health and economic consequences of obesity for individuals and society more generally. (C) 2015 Elsevier Inc. All rights reserved.