Characteristics of basolateral amygdala neuronal firing on a spatial memory task involving differential reward
Characteristics of basolateral amygdala neuronal firing on a spatial memory task involving differential reward
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DOI：
10.1037/0735-7044.112.3.554
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发表时间：
1998-06-01
影响因子：
1.9
通讯作者：
Mizumori, SJY
中科院分区：
文献类型：
--
作者：
Pratt, WE;Mizumori, SJY
先前的研究表明，空间、运动和奖励信息整合在腹侧纹状体（VS）内。本研究通过检查大鼠在 8 臂径向迷宫上进行多次记忆试验时 BLA 神经元的行为相关性，研究了杏仁核基底外侧核 (BLA) 对这种相互作用的可能贡献。交替手臂始终持有两种不同金额奖励中的一种。记录的细胞与运动、听觉输入、空间和奖励获取相关。发现与奖励相关的单位具有预期的奖励遭遇，在奖励消费期间做出反应，并区分高和低奖励幅度。这与 BLA 神经元可能为 VS 提供与奖励相关的信息的假设是一致的，然后这些信息可以与空间信息整合，最终影响目标导向的行为。
Previous research has shown that spatial, movement, and reward information is integrated within the ventral striatum (VS). The present study examined the possible contribution of the basolateral nuclei of the amygdala (BLA) to this interaction by examining behavioral correlates of BLA neurons while rats performed multiple memory trials on an 8-arm radial maze. Alternate arms consistently held 1 of 2 different amounts of reward. Recorded cells were correlated with motion, auditory input, space, and reward acquisition. Reward-related units were found that anticipated reward encounter, that responded during reward consumption, and that differentiated between high and low reward magnitude. This is consistent with the hypothesis that BLA neurons may provide the VS with reward-related information that could then be integrated with spatial information to ultimately affect goal-directed behavior.