Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report
Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report
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DOI：
10.1159/000235870
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发表时间：
2009-01-01
影响因子：
1.6
通讯作者：
Schelling, G.
中科院分区：
文献类型：
--
作者：
Kaufmann, I.;Hauer, D.;Schelling, G.
复杂性区域疼痛综合征（CRPS）是一种致残性神经性疼痛状况，可能在四肢受伤后发展。这种综合征的发病机制尚不清楚;然而，它包括神经和免疫系统之间的复杂相互作用，导致慢性炎症，疼痛和营养变化。这种相互作用可能是由慢性应激介导的，慢性应激被认为激活内源性大麻素（endocannabinoid，ECS）系统。我们进行了一项开放的，前瞻性的，比较性的临床研究，以确定内源性大麻素anandamide的血浆水平的高效液相色谱法和串联质谱系统在10例CRPS I型与10名年龄和性别匹配的健康对照。与健康对照组相比，CRPS患者显示出显著更高的血浆大麻素浓度。这些结果表明，外周ECS在CRPS中被激活。进一步的研究是必要的，以评估ECS在炎症和疼痛的限制中的作用。版权所有（C）2009 S. Karger AG，巴塞尔
The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and the immune system resulting in chronic inflammation, pain and trophic changes. This interaction may be mediated by chronic stress which is thought to activate the endogenous cannabinoid (endocannabinoid) system (ECS). We conducted an open, prospective, comparative clinical study to determine plasma level of the endocannabinoid anandamide by high-performance liquid chromatography and a tandem mass spectrometry system in 10 patients with CRPS type I versus 10 age- and sex-matched healthy controls. As compared to healthy controls, CRPS patients showed significantly higher plasma concentrations of anandamide. These results indicate that the peripheral ECS is activated in CRPS. Further studies are warranted to evaluate the role of the ECS in the limitation of inflammation and pain. Copyright (C) 2009 S. Karger AG, Basel