Cerebral metabolic response to systemic kainic acid: 14-C-deoxyglucose studies.
Cerebral metabolic response to systemic kainic acid: 14-C-deoxyglucose studies.
复制标题
大脑对全身红藻氨酸的代谢反应：14-C-脱氧葡萄糖研究。
DOI：
10.1016/0024-3205(80)90080-6
复制
发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
Olney,J
中科院分区：
文献类型：
--
作者：
Collins,RC;McLean,M;Olney,J
以12 mg/kg的剂量静脉内给予一次红藻氨酸（KA），在90分钟的时间内连续导致凝视发作、湿狗样抖动和明显的行为惊厥。惊厥持续长达18小时，随后出现食欲不振、食欲不振和惊吓。行为KA后5分钟，脱氧葡萄糖放射自显影显示海马腹侧CA 3、腹侧下托、外侧隔的葡萄糖利用增加3-6倍，背侧海马的增加不太强烈。在严重的行为性惊厥中，整个边缘系统及其皮层下投射都处于代谢活跃状态，而感觉通路和新皮层则受到抑制。在惊厥后的一到三天，参与癫痫发作的许多边缘系统区域坏死，而大脑其余部分的新陈代谢恢复正常。
Kainic acid (KA) given once intravenously in a dose of 12 mg/kg results successively in staring spells, wet dog shakes, and overt behavioral convulsions over a 90 minute time period. Convulsions last up to 18 hours and are followed by aphagia, adipsia and startle. behavior. Five minutes after KA, deoxyglucose autoradiography reveals a 3–6 fold increase in glucose utilization in ventral CA3 of hippocampus, ventral subiculum, lateral septum with a less intense increase in dorsal hippocampus. During severe behavioral convulsions the entire limbic system and its subcortical projections are metabolically active, while sensory pathways and neocortex are depressed. One to three days following convulsions many limbic areas that participated in seizures are necrotic, while metabolism in the rest of the brain has returned toward normal.