Apolipoprotein serum levels related to metabolic syndrome in patients with schizophrenia
Apolipoprotein serum levels related to metabolic syndrome in patients with schizophrenia
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DOI：
10.1016/j.heliyon.2019.e02033
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发表时间：
2019-07-01
期刊：
影响因子：
4
通讯作者：
Ivanova, Svetlana A.
中科院分区：
文献类型：
--
作者：
Boiko, Anastasiia S.;Mednova, Irina A.;Ivanova, Svetlana A.
背景：精神分裂症与心血管疾病导致的预期寿命降低有关。这至少部分地与精神分裂症患者中代谢综合征（MetS）发展的脆弱性增加有关。载脂蛋白（Apos）的调节异常可能通过影响脑胆固醇的加工而在精神分裂症的发病机制中发挥作用。目的：本研究的目的是研究精神分裂症患者血清Apos A1、C3、E、A2和C2的浓度，并与健康献血员进行比较。在获得知情同意后，纳入了53例根据ICD-10标准（F20）诊断为偏执型精神分裂症的患者。根据国际糖尿病联合会的标准将患者分为两组（N = 26）和无MetS（N = 27）。对照组包括20名身心健康的受试者。结果：精神分裂症患者血清ApoA 1水平明显低于正常对照组（P < 0.0 5（p = 0.002）;与MetS患者相比，无MetS患者的ApoA 2较低（p = 0.017），与对照组和无MetS的患者相比，MetS的精神分裂症患者的ApoC 3和ApoC 2水平升高。没有其他显着差异被建立关于其他分析apolipoproteins.Conclusions：根据文献数据，我们的研究结果表明，虽然在ApoA 1水平的干扰可能发挥作用的精神分裂症的发病机制，ApoA 2，ApoC 2，ApoC 3和ApoE可能主要与代谢失衡。
Background: Schizophrenia is associated with a lowered life expectancy due to cardiovascular disease. This is, at least in part, related to an increased vulnerability to the development of metabolic syndrome (MetS) in patients with schizophrenia. The dysregulation of apolipoproteins (Apos) may also play a role in the pathogenesis of schizophrenia via their effect on cerebral cholesterol processing.Aim: The aim of this study was to investigate serum Apos A1, C3, E, A2 and C2 concentration in schizophrenia patients with or without MetS in comparison to healthy donors.Methods: After obtaining informed consent, 53 patients with a diagnosis of paranoid schizophrenia according to ICD-10 criteria (F20) were included. Patients were divided into two groups with (N = 26) and without (N = 27) MetS according to the criteria of the International Diabetes Federation. The control group included 20 mentally and physically healthy subjects. Serum Apos A1, A2, C2, C3 and E were measured using xMAP technology (Luminex).Results: Serum ApoA1 was significantly decreased in patients with schizophrenia compared to healthy subjects (p = 0.002); ApoA2 was lower in patients without MetS in comparison to patients with MetS (p = 0.017) and the levels of ApoC3 and ApoC2 were increased in patients with schizophrenia with MetS in comparison with the control group and also with patients without MetS. No other significant differences were established concerning the other assayed apolipoproteins.Conclusions: In line with literature data the results of our study suggest that while disturbances in ApoA1 level may play a role in the pathogenesis of schizophrenia, ApoA2, ApoC2, ApoC3 and ApoE may be primarily related to metabolic imbalance.