Comparison of the differential distribution of leukocytes in preeclampsia versus uncomplicated pregnancy
Comparison of the differential distribution of leukocytes in preeclampsia versus uncomplicated pregnancy
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DOI：
10.1159/000009973
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发表时间：
1998-01-01
影响因子：
2.1
通讯作者：
Tuvbin, Y
中科院分区：
文献类型：
--
作者：
Lurie, S;Frenkel, E;Tuvbin, Y
目的：探讨子痫前期与无并发症妊娠的白细胞计数及差异分布。研究设计：从46例连续的子痫前期患者和46例无并发症妊娠的对照组中获得血液样本。30人符合轻度子痫前期的标准，16人符合重度子痫前期的标准。静脉穿刺后1小时内验血。在cell - dyn 2000中检测血液的全血细胞计数。主要结果：子痫前期患者中性粒细胞绝对计数明显高于无并发症妊娠对照组（9410.1 +/- 3066.9 vs 7498.6 +/- 2354.0 × 10(6)/l, p < 0.05）。在中性粒细胞方面，与轻度子痫前期患者相比，重度子痫前期患者中性粒细胞升高更为显著（10,658.8 +/- 3520.4 vs 8,694.4 +/- 2,561.9 x 10(6)/l, p < 0.05）。子痫前期患者的绝对淋巴细胞和嗜酸性粒细胞计数与非并发症妊娠相比下降，而单核细胞和嗜碱性粒细胞计数没有差异。结论：我们的结果提示先兆子痫。与绝对中性粒细胞计数的增加有关。
Objective: To describe leukocyte count and differential distribution in preeclampsia and uncomplicated pregnancy. Study design: Blood samples were obtained from 46 consecutive preeclamptic patients and 46 controls with uncomplicated pregnancy. Thirty met the criteria for mild preeclampsia and 16 for severe. The blood was tested within 1 h of venepuncture. An aliquot of the blood was tested in the Cell-Dyn 2000 for complete blood cell count. Main Results: The absolute neutrophil count was significantly elevated in preeclamptic patients as compared with that of controls with uncomplicated pregnancy (9,410.1 +/- 3,066.9 vs. 7,498.6 +/- 2,354.0 x 10(6)/l, p < 0.05). In neutrophils, the elevation was more prominent in severe preeclamptic patients as compared with mild preeclamptic patients (10,658.8 +/- 3520.4 vs. 8,694.4 +/- 2,561.9 x 10(6)/l, p < 0.05). The absolute lymphocyte and eosinophil counts declined in patients with preeclampsia as compared with uncomplicated pregnancy, whereas monocyte and basophil counts did not differ. Conclusion: Our results suggest that preeclampsia. is associated with an increase in the absolute neutrophil count.