Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix: The final results
Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix: The final results
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DOI：
10.1006/gyno.1997.4812
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发表时间：
1997-10-01
影响因子：
4.7
通讯作者：
diPaola, G
中科院分区：
文献类型：
--
作者：
Sardi, JE;Giaroli, A;diPaola, G
目的：确定50 mg/m(2)顺铂、1 mg/m(2)长春新碱和25 mg/m(2)博来霉素（1-3天）组成的三个疗程（间隔10天）是否能改善Wertheim-Meigs +放疗前的生存。材料：将250例未选择的Ib期患者（肿瘤直径> ~ 2cm）随机分为两组：(1)对照组103例患者（56例体积较大，> ~ 4cm直径），采用Wertheim-Meigs（如果肿瘤可自由切除）+全骨盆辅助放疗（仅在主动脉旁淋巴结转移患者中使用扩展野放疗）。当肿瘤无法切除时，进行手术分期并选择放射治疗。(2)新辅助组（102例，61例）先进行新辅助化疗，再进行与对照组相同的治疗。结果：在67（31-102）个月的随访后，肿瘤直径为4cm和4cm的Ib期患者未见差异。(C) 1997学术出版社。
Objective: To determine if three courses consisting of 50 mg/m(2) cis-platinum, 1 mg/m(2) vincristine, and 25 mg/m(2) bleomycin (day 1-3) at 10-day intervals can improve survival before Wertheim-Meigs + radiotherapy.Material: Two hundred five unselected stage Ib patients (having tumors >2 cm in diameter) were divided into two groups at random: (1) The group control consisted of 103 patients (56 bulky, >4 cm diameter) treated with Wertheim-Meigs (if the tumor was resectable with free surgical margins) + adjuvant radiotherapy to whole pelvis (extended field radiation was used only in patients with paraaortic lymph node metastases). When the tumor was unresectable, a surgical staging was performed and radiotherapy was the chosen treatment. (2) Neoadjuvant (102 patients, 61 bulky) had neoadjuvant chemotherapy and then the same treatment as the control patients.Results: After 67 (31-102) months of follow-up, no difference was seen in tumors >2 and 4 cm diameter) stage Ib patients. (C) 1997 Academic Press.