Whisker trimming begun at birth or on postnatal day 12 affects excitatory and inhibitory receptive fields of layer IV barrel neurons.
Whisker trimming begun at birth or on postnatal day 12 affects excitatory and inhibitory receptive fields of layer IV barrel neurons.
复制标题
出生时或出生后第 12 天开始的胡须修剪会影响第四层桶状神经元的兴奋性和抑制性感受野。
DOI：
10.1152/jn.00569.2005
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Simons,DanielJ
中科院分区：
文献类型：
--
作者：
Shoykhet,Michael;Land,PeterW;Simons,DanielJ
在大鼠中，在发育过程中修剪胡须会导致皮质桶回路功能的持续改变，并在以后的生活中导致行为缺陷。在这里，我们研究了如何胡须修剪开始无论是在出生时（P0）或出生后第12天（P12），在发病的搅拌行为，影响感受野的第四层桶神经元。将左侧面部的所有胡须修剪40-45天，然后使其完全再生。细胞外单单位记录和控制偏转的主要和相邻的晶须（PW和AW，分别），单独或成对的组合，被用来评估兴奋和抑制作用的相邻的晶须桶神经元。结果表明，从P0和P12的胡须修剪导致IV层神经元的兴奋性感受野扩大和抑制性感受野减弱。PW-和AW-诱发的反应是更大的幅度在修剪比对照组动物; AW-诱发的反应不成比例的影响，减少桶神经元的空间焦点。P12后的去甲占P0修剪动物中观察到的总效应的约50%。抑制性的相互作用，诱发的两个胡须偏转连续，是较弱的修剪比对照组动物。然而，抑制性尾/喙和腹/背梯度似乎不受感觉剥夺的影响。因此，经验持续修改成熟的桶回路的发育期延伸到并可能超过搅拌行为的开始。在此期间的感觉剥夺影响桶神经元的兴奋性和抑制性感受野的发育，并可能损害来自多个胡须的感觉信息的皮质整合。
In rats, whisker trimming during development leads to persistent alterations in the function of cortical barrel circuits and to behavioral deficits later in life. Here we examined how whisker trimming begun either at birth (P0) or on postnatal day 12 (P12), around the onset of whisking behavior, affects receptive fields of layer IV barrel neurons. All whiskers on the left face were trimmed for 40–45 days and then allowed to regrow fully. Extracellular single-unit recordings and controlled deflections of principal and adjacent whiskers (PW and AW, respectively), individually or in paired combinations, were used to assess excitatory and suppressive effects of neighboring whiskers on barrel neurons. Results indicate that whisker trimming both from P0 and P12 leads to enlarged excitatory and weakened inhibitory receptive fields in layer IV neurons. PW- and AW-evoked responses are larger in magnitude in trimmed than in control animals; AW-evoked responses are disproportionately affected, decreasing the spatial focus of barrel neurons. Deprivation after P12 accounts for ∼50% of the total effect observed in P0 trimmed animals. Suppressive interactions, evoked by two whiskers deflected in succession, are weaker in trimmed than in control animals. Suppressive caudal/rostral and ventral/dorsal gradients, however, seem unaffected by sensory deprivation. Thus the developmental period during which experience persistently modifies maturing barrel circuitry extends up to and likely beyond the onset of whisking behavior. Sensory deprivation during this time affects development of both excitatory and inhibitory receptive fields of barrel neurons and likely impairs cortical integration of sensory information from multiple whiskers.
登录
查看更多内容
影响因子：
5
作者：
RUCH, LO;CHANDLER, SM;HARTER, RA
通讯作者：
HARTER, RA
DOI：
10.1111/j.1939-0025.1988.tb01572.x
发表时间：
1988
期刊：
The American journal of orthopsychiatry
影响因子：
--
作者：
F. Sink
通讯作者：
F. Sink
心理健康与犯罪受害的相关性：一项随机社区调查。
影响因子：
5.9
作者：
D. Kilpatrick;C. Best;Lois J. Veronen;Angelynne E. Amick;Lorenz A. Villeponteaux;G. A. Ruff
通讯作者：
G. A. Ruff
影响因子：
4.8
作者：
FREEMAN, RJ;BEACH, B;SOLYOM, L
通讯作者：
SOLYOM, L
酗酒女性的性功能障碍和治疗
影响因子：
1.5
作者：
W. Murphy;E. Coleman;E. Hoon;Cheryl Scott
通讯作者：
Cheryl Scott