Calcific aortic stenosis: medical and surgical management in the elderly.
Calcific aortic stenosis: medical and surgical management in the elderly.
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DOI：
10.1007/s11936-005-0028-9
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发表时间：
2005-12-01
影响因子：
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通讯作者：
Rajamannan, Nalini M
中科院分区：
文献类型：
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作者：
Rajamannan, Nalini M
钙化性主动脉狭窄是美国外科瓣膜置换术的头号适应症。直到最近，这还被认为是一个被动的退化过程。然而，最近的回顾性研究表明，瓣膜疾病的危险因素与血管疾病的危险因素相似。此外，以药物治疗为目标的这一过程可能是未来推迟这一患者群体瓣膜置换时机的可能性。本文综述了当前的回顾研究、实验研究和未来的临床试验，这些研究将影响我们对这一疾病过程的理解和对这些患者的药物治疗的未来。
Calcific aortic stenosis is the number one indication for surgical valve replacement in the United States. Until recently, it was thought to be a passive degenerative process. However, recent retrospective studies have demonstrated that the risk factors for valvular disease are similar to those of vascular disease. Furthermore, targeting this process with medical therapy may be a future possibility to delay timing of valve replacement in this patient population. This paper reviews the current retrospective studies, experimental studies, and future clinical trials that will impact our understanding of this disease process and the future of medical therapy for these patients.