Mooren's ulcer
Mooren's ulcer
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DOI：
10.1097/00004397-199603610-00003
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发表时间：
1996-12-01
影响因子：
--
通讯作者：
Foster, CS
中科院分区：
文献类型：
--
作者：
Chow, CYC;Foster, CS
蚕蚀性角膜溃疡，也称为慢性匐行性溃疡和啮齿类溃疡，由 Bowman 于 1849 年首次描述[1]。 Mooren 于 1867 年发表了详细描述该疾病的病例，并将其确立为一个独特的临床实体 [1]。蚕蚀性溃疡是一种疼痛的、持续性的慢性溃疡性角膜炎，从周边开始并向周向和中央进展。根据定义，它是特发性的，这意味着它发生在没有任何可归因于溃疡性角膜炎的全身性疾病的情况下。其确切的病理生理学仍不确定。这种疾病的治疗已取得进展，但很大一部分病例对现有疗法仍然无效，并导致严重的视力障碍。
Mooren's ulcer of the cornea, also known as chronic serpiginous ulcer and ulcus rodens, was first described by Bowman in 1849 [1]. Mooren, in 1867, published cases describing the disorder in detail and establishing it as a distinct clinical entity [1]. Mooren's ulcer is a painful, relentless, chronic ulcerative keratitis that begins peripherally and progresses circumferentially and centrally. It is, by definition, idiopathic, meaning that it occurs in the absence of any systemic disorder to which an ulcerative keratitis may be attributed. Its exact pathophysiology remains uncertain. Advances have been made in the management of this disorder, but a significant percentage of cases remain refractory to available therapies and result in severe visual morbidity.