Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis
Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis
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DOI：
10.1016/s0959-8049(00)00156-8
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发表时间：
2000-08-01
影响因子：
8.4
通讯作者：
Murray, GI
中科院分区：
文献类型：
--
作者：
Curran, S;Murray, GI
基质金属蛋白酶（matrix metalloproteinases，MMPs）是一类蛋白水解酶，其生理功能包括组织重塑和胚胎发生。这组蛋白质在肿瘤侵袭和转移过程中的重要性现在已被广泛认识，并导致了对MMP抑制剂在临床环境中用作抗癌治疗的研究。这篇评论的目的是使读者最新与目前的研究有关的基质金属蛋白酶，特别强调新兴的机制，这些酶的调节，以及它们与细胞粘附分子的相互作用。还将讨论MMPs的治疗性抑制。(C)2000爱思唯尔科技有限公司版权所有。
The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, whose physiological functions include tissue remodelling and embryogenesis. Thc importance of this group of proteins in the processes of tumour invasion and metastasis is now widely acknowledged, and has led to the search for MMP inhibitors for use as anticancer treatments in a clinical setting. This review aims to bring the reader up-to-date with current research relating to MMPs, with particular emphasis on emerging mechanisms of regulation of these enzymes, and their interaction with cell adhesion molecules. The therapeutic inhibition of MMPs will also be discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.