EFFECT OF GROWTH ON VARIABILITY OF LEFT-VENTRICULAR MASS - ASSESSMENT OF ALLOMETRIC SIGNALS IN ADULTS AND CHILDREN AND THEIR CAPACITY TO PREDICT CARDIOVASCULAR RISK
EFFECT OF GROWTH ON VARIABILITY OF LEFT-VENTRICULAR MASS - ASSESSMENT OF ALLOMETRIC SIGNALS IN ADULTS AND CHILDREN AND THEIR CAPACITY TO PREDICT CARDIOVASCULAR RISK
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DOI：
10.1016/0735-1097(94)00540-7
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发表时间：
1995-04-01
影响因子：
24
通讯作者：
LARAGH, JH
中科院分区：
文献类型：
--
作者：
DESIMONE, G;DEVEREUX, RB;LARAGH, JH
目标。我们试图确定生长是否影响左心室质量与体型之间的关系，以及使用不同体型指标是否影响心室质量预测高血压并发症的能力。最近报道了左心室质量和身高之间的异速（或生长）信号，以改进先前的方法，使心室质量与体型归一化。对611名4个月至70岁血压正常、体重正常的受试者和383名儿童的左室质量-高度关系残差（2.7）进行了分析。结果表明：1)在人的生长过程中，左心室质量随身高的增加而变化；2)成人和儿童左室质量与身高的异速生长信号低于整个年龄谱；3)基于高度的左室质量指标至少维持并可能增强高血压左室肥厚的心脏风险预测；4)在整个年龄谱中得出的异速生长信号似乎比在成人中计算的更有助于预测心血管风险。
Objectives. We sought to determine whether growth influences the relation between left ventricular mass and body size and whether use of different body size indexes affects the ability of ventricular mass to predict complications of hypertension.Background. Allometric (or growth) signals between left ventricular mass and height have recently been reported to improve previous approaches for normalization of ventricular mass for body size.Methods. Residuals of left ventricular mass-height(2.7) relations were analyzed in a learning series of 611 normotensive, normal weight subjects 4 months to 70 years old and, separately, in 383 children ( 0.1).Conclusions. These results show the following: 1) Variability of left ventricular mass in relation to height increases during human growth; 2) allometric signals of left ventricular mass versus height are lower in adults and children than those obtained across the entire age spectrum; 3) height-based indexes of left ventricular mass at least maintain and may enhance prediction of cardiac risk by hypertensive left ventricular hypertrophy; and 4) the allometric signal derived across the entire spectrum of age appears to be more useful for prediction of cardiovascular risk than that computed in adults.