(18) F-FDG PET imaging of rheumatoid articular and extraarticular synovitis.
(18) F-FDG PET imaging of rheumatoid articular and extraarticular synovitis.
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(18) 类风湿关节和关节外滑膜炎的F-FDG PET显像。
DOI：
10.1097/rhu.0b013e318188e230
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
M. Scheinberg
中科院分区：
文献类型：
--
作者：
A. Fonseca;J. Wagner;L. Yamaga;Akemi Osawa;M. L. da Cunha;M. Scheinberg
在过去的几年中(18)，F-FDG荧光脱氧葡萄糖正电子发射断层扫描(FDG-PET)在肿瘤分期和治疗监测方面取得了重大进展。FDG-PET也可用于活动性滑膜炎的成像，目前正在评估其在监测治疗中的有效性。患者DGC为62岁男性，长期患有类风湿性关节炎。他对DMARDS没有反应，被分配到生物治疗。他在6周内接受了3次英夫利昔单抗的注射。他在第一次注射前和注射后2个月采集了全身FDG-PET图像(图1和图2)。图像分析显示FDG在几个关节中显着摄取，表明治疗前代谢活动严重，抗肿瘤坏死因子治疗后显着减少。治疗前后DAS28分别为5.6和3.4，
During the past few years (18) F-FDG fluor deoxyglucose positron emission tomography (FDG-PET) has become a major advance in the staging of tumors and monitoring of treatment. FDG-PET can also be used to image active synovitis and its usefullness in monitoring treatment is currently being evaluated. Patient DGC is a 62-year-old male attending our clinic with long standing rheumatoid arthritis. He failed to respond to DMARDs and was assigned to biologic therapy. He received 3 infusions of Infliximab in a 6 week period. He had whole body FDG-PET images acquired prior to and 2 months after the first infusion (Figs. 1 and 2). Image analysis shows significant uptake of FDG in several joints indicating severe metabolic activity before treatment followed by marked reduction after anti TNF therapy. DAS28 before and after therapy was 5.6 and 3.4,