Clustering and switching in semantic fluency: predictors of the development of Alzheimer's disease
Clustering and switching in semantic fluency: predictors of the development of Alzheimer's disease
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DOI：
10.1002/gps.2025
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发表时间：
2008-10-01
影响因子：
4
通讯作者：
Salamero, Manel
中科院分区：
文献类型：
--
作者：
Fagundo, Ana B.;Lopez, Samuel;Salamero, Manel
目的本研究的目的有两个：（1）比较记忆障碍者、阿尔茨海默病（AD）患者和健康对照者的语义流畅性、聚类和转换能力;和（2）检查聚类/方法采用语义流畅性任务对38名被试进行比较对42名AD患者和25名健康对照者的记忆投诉进行了总单词生成数、聚类和切换性能的研究。对有记忆投诉的受试者进行了最长两年的随访，并进行了重新评估。结果AD患者产生的正确单词较少（p < 0.001），聚类（p = 0.008）和转换（p < 0.001）减少。与对照组相比，有记忆障碍的受试者在正确单词（p < 0.001）和聚类性能（p = 0.008）方面表现出显著降低。在第一次评估中，在随访时转化为AD的患者亚组产生的正确单词较少（p < 0.01），聚类较小（p = 0.007）。这两个亚组之间的转换没有差异。AD的发展是更好地预测集群的大小比由总的单词数产生或通过switching.Conclusions主题与记忆投诉和AD患者的语义流畅性的定性和定量方面的改变。聚类分析可以提高AD早期诊断的可靠性。版权所有（C），2008约翰威利父子有限公司
Objective The aims of the study are twofold: (1) to compare semantic fluency, clustering and switching performance among subjects with memory complaints, patients with Alzheimer Disease (AD), and healthy controls; and (2) to examine the clinical utility of the clustering/switching scoring system in the prediction of incident AD in subjects with memory complaints.Methods A semantic fluency task was used to compare thirty eight subjects with memory complaints, forty two AD patients and twenty five healthy controls on the total number of words generated, clustering and switching performance. Subjects with memory complaints were followed-up for a maximum period of two years and re-evaluated. They remained in the memory complaints group (twenty eight subjects) or were defined as probable AD (ten subjects).Results AD patients generated fewer correct words (p < 0.001) and showed a reduction in clustering (p = 0.008) and switching (p < 0.001). Subjects with memory complaints showed a significant reduction in correct words (p < 0.001) and clustering performance (p = 0.008) compare to controls. In the first evaluation, the subgroup of patients who converted to AD at follow up produced less correct words (p < 0.01) and smaller clusters (p = 0.007) than the subgroup who did not become demented. There were no differences in switching between these two subgroups. AD development was better predicted by cluster size than by the total number of words generated or by switching.Conclusions Subjects with memory complaints and AD patients have an alteration in both qualitative and quantitative aspects of semantic fluency. A clustering analysis could enhance the reliability of early AD diagnosis. Copyright (C), 2008 John Wiley & Sons, Ltd.