Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: An fMRI study
Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: An fMRI study
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DOI：
10.1002/hbm.20415
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发表时间：
2008-05-01
影响因子：
4.8
通讯作者：
Williams, Leanne M.
中科院分区：
文献类型：
--
作者：
Bryant, Richard A.;Kemp, Andrew H.;Williams, Leanne M.
创伤后应激障碍（PTSD）的生物学模型表明，在处理恐惧刺激时，患者会表现出杏仁核增强而内侧前额叶活动减弱。然而，对无意识恐惧信号的快速和自动报警机制表明，在无意识的恐惧刺激处理下，创伤后应激障碍可能表现出更高而不是更低的MPFC。本研究使用功能性磁共振成像技术检测了15名PTSD患者和15名年龄和性别匹配的健康对照者在恐惧和中性面孔无意识呈现（16.7 ms，蒙面）时血氧水平依赖性信号的变化。结果表明，PTSD参与者在无意识处理恐惧面孔时，杏仁核和MPFC的活动增加。这些数据扩展了现有的模型，表明创伤后应激障碍中受损的MPFC激活可能仅限于有意识的恐惧处理。
Biological models of posttraumatic stress disorder (PTSD) suggest that patients will display heightened amygdala but decreased medial prefrontal activity during processing of fear stimuli. However, a rapid and automatic alerting mechanism for responding to nonconscious signals of fear suggests that PTSD may display heightened rather than decreased MPFC under nonconscious processing of fear stimuli. This study used functional magnetic resonance imaging to examine blood oxygenation level-dependent signal changes during nonconscious presentation (16.7 ms, masked) of fearful and neutral faces in 15 participants with PTSD and 15 age and sex-matched healthy control participants. Results indicate that PTSD participants display increased amygdala and MPFC activity during nonconscious processing of fearful faces. These data extend existing models by suggesting that the impaired MPFC activation in PTSD may be limited to conscious fear processing.