The effect of gas permeability of film dressings on wound environment and healing.
The effect of gas permeability of film dressings on wound environment and healing.
复制标题
薄膜敷料透气性对伤口环境及愈合的影响。
DOI：
10.1111/1523-1747.ep12284076
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发表时间：
1989
影响因子：
6.5
通讯作者：
D. Grussing
中科院分区：
文献类型：
--
作者：
L. M. Sirvio;D. Grussing
我们已经确定了薄膜敷料的氧气和二氧化碳渗透性对家猪伤口渗出液 P O2、P CO2、pH 和浅伤口上皮化的影响。比较了三种薄膜：聚偏二氯乙烯，一种低透气性薄膜；聚氨酯，中等透气性薄膜；以及聚（二甲基硅酮），一种高透气性薄膜。硅胶膜下的渗出液中P O2 最高，P CO2 最低；聚氨酯下的渗出物有中间体P O2 和P CO2 ；聚偏二氯乙烯下渗出液的P O2 最低，P CO2 最高。薄膜下的 pH 值与 P CO2 成反比。气体张力和pH值反映了薄膜控制氧气扩散到伤口渗出液和二氧化碳从伤口渗出液中损失的能力。聚偏二氯乙烯和聚氨酯下2天和3天的平均上皮化值没有显着差异，但均高于硅胶膜下。我们从数据中推断，使用氧气和二氧化碳不渗透的薄膜敷料不会影响灌注良好的浅伤口的上皮化。使用有机硅薄膜（对氧气和二氧化碳具有高渗透性）会导致二氧化碳损失。由此产生的相对较高的 pH 值可能是导致有机硅膜下方发生上皮化速率降低的原因。
We have determined the effect of oxygen and carbon dioxide permeability of thin film dressings on wound exudate P O2, P CO2, pH, and epithelialization in shallow wounds on domestic pigs. Three kinds of films were compared: polyvinylidine chloride, a low gas permeability film; polyurethane, a medium gas permeability film; and poly(dimethyl silicone), a high gas permeability film. Exudate under the silicone film had the highest P O2 and the lowest P CO2; exudate under the polyurethane had intermediate P O2 and P CO2; and exudate under the polyvinylidine chloride had the lowest P O2 and highest P CO2. Values for pH under the films correlated inversely with P CO2. The gas tensions and pH are a reflection of the ability of the films to control the diffusion of oxygen into and the loss of carbon dioxide from the wound exudate. Mean epithelialization values at 2 and 3 d were not significantly different under polyvinylidine chloride and polyurethane, but both were higher than under the silicone film. We infer from the data that the use of oxygen and carbon dioxide impermeable film dressings do not affect epithelialization in well-perfused, shallow wounds. The use of the silicone film (highly permeable to both oxygen and carbon dioxide) led to a loss of carbon dioxide. The resulting relatively high pH may have been responsible for the reduced rate of epithelialization which occurred beneath the silicone film.