Lymph node stromal cells: diverse meshwork structures weave functionally subdivided niches
Lymph node stromal cells: diverse meshwork structures weave functionally subdivided niches
复制标题
淋巴结基质细胞：不同的网状结构编织出功能细分的生态位
DOI：
10.1007/978-3-030-86016-5_5
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Takeuchi;A.;Ozawa;M.;Cui;G.;Ikuta;K.;and Katakai;T.
淋巴结（LN）是次级淋巴器官，其作为抵抗侵入性异物的第一道防线发挥作用。在LN内，不同类型的免疫细胞被策略性地定位以有效地诱导免疫应答。这种复杂的组织结构是由多种成纤维细胞基质细胞构建的功能特化小生境的复合体。阐明小生境和基质细胞的特性和功能将有助于理解LN诱导的免疫应答。最近的三项研究为特化基质细胞提供了新的见解。在我们对这些令人惊讶的多样化基质细胞的讨论中，我们将整合这些研究的信息，以提高对LN结构和小生境的认识。
Lymph nodes (LNs) are secondary lymphoid organs that function as the first line of defense against invasive foreign substances. Within the LNs, different types of immune cells are strategically localized to induce immune responses efficiently. Such a sophisticated tissue structure is a complex of functionally specialized niches, constructed by a variety of fibroblastic stromal cells. Elucidating the characteristics and functions of the niches and stromal cells will facilitate comprehension of the immune response induced in the LNs. Three recent studies offered novel insights into specialized stromal cells. In our discussion of these surprisingly diverse stromal cells, we will integrate information from these studies to improve knowledge about the structure and niches of LN.