Alterations in the epithelial surface of human palatal shelves prior to and during fusion: A scanning electron microscopic study
Alterations in the epithelial surface of human palatal shelves prior to and during fusion: A scanning electron microscopic study
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融合前和融合期间人类腭架上皮表面的变化：扫描电子显微镜研究
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
S. Meller
中科院分区：
文献类型：
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作者：
R. Waterman;S. Meller
通过扫描电子显微镜检查了72个治疗性流产的人类胚胎和胎仔（年龄范围为37天至12周（受精后））在继发性腭形成之前和期间的腭架表面形貌。在支架接触前，在预期融合区域观察到上皮表面外观的改变。首先观察到沿假定内侧边缘前部沿着的椭圆形区域，在支架接触之前，改变区沿内侧边缘的前部沿着逐渐扩展，并随着融合的进行，沿支架的后部沿着扩展。改变的区域最终延伸到搁板中间的口腔表面，但仅限于沿着内侧边缘向后的狭窄区域。最初的特征是表面细胞的伸长和“缠绕”，后来的变化包括细胞死亡、脱落和表面细胞可能的主动迁移。改变区下的搁板上皮厚度不规则性增加，并有许多“内陷”进入下层间质。这些变化被认为反映了大陆架内部的内在变化，并可能在融合过程中发挥作用。还观察到融合后表面重塑的证据。
The surface topography of palatal shelves was examined by scanning electron microscopy prior to and during secondary palate formation in 72 therapeutically aborted human embryos and fetuses ranging in age from 37 days to 12 weeks (post‐fertilization). Alterations in epithelial surface appearance were observed in the prospective region of fusion prior to contact between the shelves. First seen as an elliptical area along the anterior portion of the presumptive medial edge, a zone of alteration spread progressively along the anterior four‐fifths of the medial edge prior to shelf contact, and continued along the posterior one‐fifth of the shelf as fusion proceeded. The altered zone eventually extended onto the oral surface in the middle of the shelf but was restricted to a narrow zone along the medial edge posteriorly. Initially characterized by elongation and “intertwining” of superficial cells, alterations later included cell death, desquamation and possible active migration of surface cells. The shelf epithelium subjacent to the zone of alteration exhibited increased irregularity in thickness and numerous “invaginations” into the underlying mesenchyme. These alterations are thought to reflect intrinsic changes within the shelf and may play a role in the fusion process. Evidence for surface remodeling following fusion was also observed.