Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report.
Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report.
复制标题
与妊娠期达特茅斯联合化疗相关的小眼球：病例报告。
DOI：
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发表时间：
2007
影响因子：
0.2
通讯作者：
T. Lau
中科院分区：
文献类型：
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作者：
R. Li;W. Tam;P. Ng;T. Mok;B. Tam;T. Lau
背景
妊娠期使用达特茅斯联合化疗的报道很少，只有1例报告在妊娠晚期和妊娠晚期使用，没有报告在妊娠早期使用。
情况
这是第一个报告的病例，其中达特茅斯联合化疗方案无意中用于治疗转移性黑色素瘤的孕妇在第一和第二个三个月。婴儿被发现有孤立的小眼球和严重的远视在1岁。
结论
虽然不能从单个病例中建立因果关系，但本报告确实提供了有用的信息，以阻止在头三个月使用这种化疗方案，这是器官形成的关键时期。
BACKGROUND
Use of Dartmouth combination chemotherapy in pregnancy is scarcely reported, with only 1 report of its use in the late second and third trimesters and no report of its use in the first trimester.
CASE
This is the first reported case in which the Dartmouth combination chemotherapy regimen was inadvertently used in a pregnant woman during the first and second trimesters for treatment of metastatic melanoma. The infant was found to have isolated microphthalmos and severe hypermetropia at 1 year of age.
CONCLUSION
Although a causal relationship cannot be established from a single case, this report does provide useful information to discourage the use of this chemotherapy regimen in the first trimester, which is the critical period for organogenesis.