Genetically determined variation in the complement system: relationship to disease.
Genetically determined variation in the complement system: relationship to disease.
复制标题
补体系统中遗传决定的变异：与疾病的关系。
DOI：
10.1016/s0022-3476(84)80110-9
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Winkelstein,JA
中科院分区：
文献类型：
--
作者：
McLean,RH;Winkelstein,JA
补体系统由许多血清蛋白组成，当它们以有序和整合的方式发挥作用时，它们是宿主防御和炎症的重要介质。补体系统的激活既可以对宿主有益，如抵抗入侵的微生物，也可以对宿主有害，如在各种免疫病理介导的疾病中。我们总结了目前的知识，补体系统，其变异性的遗传基础，个体之间，这种变异性与人类疾病的关系。
TIlE COMPLEMENT SYSTEM is composed of a number of serum proteins that, when functioning in an orderly and integrated fashion, serve as important mediators of host defense and inflammation? Activation of the complement system can either be beneficial to the host, as in resistance to invading microorganisms, or it can be detrimental to the host, as in a variety of immunopathologically mediated disease.During the past two decades much new knowledge concerning the genetics of the complement system has led to a better understanding of several clinically significant conditions. We summarize current knowledge about the complement system, the genetic basis for its variability among individuals, and the relationship of that variability to human disease.