Evidence supporting the inclusion of strains from each of the two co-circulating lineages of H3N8 equine influenza virus in vaccines
Evidence supporting the inclusion of strains from each of the two co-circulating lineages of H3N8 equine influenza virus in vaccines
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DOI：
10.1016/j.vaccine.2004.02.048
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发表时间：
2004-09-28
期刊：
影响因子：
5.5
通讯作者：
Mumford, JA
中科院分区：
文献类型：
--
作者：
Daly, JM;Yates, PJ;Mumford, JA
两种抗原性不同的马流感A H3N8亚型病毒，在美国和欧洲共同传播。在小马身上进行了实验，研究了含有单一谱系病毒的疫苗对同源或异源病毒攻击感染的保护作用。回归分析显示，接种了攻毒前单一放射状溶血（SRH）抗体平均水平（即45-190 mm(2)）的小马，如果接种了攻毒株的异源病毒，感染的可能性要高于接种同源病毒的小马。对纯种马的实地研究也表明，含有欧洲谱系毒株的疫苗诱导的SRH抗体水平大于或等于150mm(2)，对来自同一谱系的病毒感染具有保护作用，但相同或更高的抗体水平可能对美国谱系病毒没有保护作用。总之，疫苗应包含代表两种H3N8亚型谱系的病毒株，以最大限度地防止感染。(C) 2004 Elsevier Ltd.版权所有。
Two lineages of antigenically distinct equine influenza A H3N8 subtype viruses, American and European, co-circulate. Experiments were conducted in ponies to investigate the protection induced by vaccines containing virus from one lineage against challenge infection with homologous or heterologous virus. Regression analysis showed that vaccinated ponies with average pre-challenge single radial haemolysis (SRH) antibody levels (i.e. 45-190 mm(2)) had a higher probability of becoming infected if they were vaccinated with virus heterologous to the challenge strain than if they were vaccinated with homologous virus. Field studies in Thoroughbred racehorses also showed that SRH antibody levels of greater than or equal to150 mm(2) induced by vaccines containing a European lineage strain are protective against infection with a virus from the same lineage, but that the same or higher antibody levels may not be protective against an American lineage virus. In conclusion, vaccines should contain virus strains representative of both H3N8 subtype lineages to maximise protection against infection. (C) 2004 Elsevier Ltd. All rights reserved.