Scroll wave dynamics in a three-dimensional cardiac tissue model: Roles of restitution, thickness, and fiber rotation
Scroll wave dynamics in a three-dimensional cardiac tissue model: Roles of restitution, thickness, and fiber rotation
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DOI：
10.1016/s0006-3495(00)76821-4
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发表时间：
2000-06-01
影响因子：
3.4
通讯作者：
Weiss, JN
中科院分区：
文献类型：
--
作者：
Qu, ZL;Kil, K;Weiss, JN
涡旋波(涡旋)分解被认为是室颤的基础，室颤是心源性猝死的主要原因。我们使用Luo-Rudy(LR1)动作电位模型的I相来模拟三维心脏组织模型中的涡卷波行为。研究了动作电位时程恢复、组织厚度、纤维缠绕和纤维旋转等因素对动作电位恢复的影响。我们发现，在该心脏模型中，动作电位时程恢复是涡卷波行为的主要决定因素，而由时程恢复引起的不稳定性是涡卷波破裂的主要决定因素。我们在LR1模型中没有看到“厚度诱导的不稳定性”，但在纤维旋转存在的情况下，涡旋破裂需要一个最小厚度。纤维旋转的主要作用是在涡旋波中保持加捻，促进长丝弯曲，从而使涡旋断裂。此外，纤维的旋转会在涡旋波中引起曲率，从而削弱传导，进一步促进波的破裂。
Scroll wave (vortex) breakup is hypothesized to underlie ventricular fibrillation, the leading cause of sudden cardiac death. We simulated scroll wave behaviors in a three-dimensional cardiac tissue model, using phase I of the Luo-Rudy (LR1) action potential model. The effects of action potential duration (APD) restitution, tissue thickness, filament twist, and fiber rotation were studied. We found that APD restitution is the major determinant of scroll wave behavior and that instabilities arising from APD restitution are the main determinants of scroll wave breakup in this cardiac model. We did not see a "thickness-induced instability" in the LR1 model, but a minimum thickness is required for scroll breakup in the presence of fiber rotation. The major effect of fiber rotation is to maintain twist in a scroll wave, promoting filament bending and thus scroll breakup. In addition, fiber rotation induces curvature in the scroll wave, which weakens conduction and further facilitates wave break.