Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.
Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.
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DOI：
10.1038/ncomms7385
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发表时间：
2015-02-27
影响因子：
16.6
通讯作者：
Giacobini, Paolo
中科院分区：
文献类型：
--
作者：
Parkash, Jyoti;Messina, Andrea;Langlet, Fanny;Cimino, Irene;Loyens, Anne;Mazur, Daniele;Gallet, Sarah;Balland, Eglantine;Malone, Samuel A.;Pralong, Francois;Cagnoni, Gabriella;Schellino, Roberta;De Marchis, Silvia;Mazzone, Massimiliano;Pasterkamp, R. Jeroen;Tamagnone, Luca;Prevot, Vincent;Giacobini, Paolo
哺乳动物的生殖能力取决于促性腺激素释放激素（GnRH）神经元向下丘脑正中隆起（ME）的投射和GnRH向下丘脑-垂体-性腺轴的及时释放。在成年啮齿类动物中，GnRH神经元和称为伸长细胞的特化胶质细胞周期性地经历细胞骨架可塑性。然而，调节这种可塑性的机制在很大程度上仍然未知。我们表明，Semaphorin 7A，由tanycells表达，起着双重作用，诱导收缩的GnRH终端和促进他们的ensheathment由tanycytic结束脚通过受体丛蛋白C1和Itgb 1，分别。此外，Semaphorin 7A的表达在发情周期期间受到性腺类固醇水平波动的调节。小鼠脑信号蛋白7A受体的遗传失效会诱导ME中的神经元和神经胶质细胞重排，并消除正常的动情周期和生育能力。这些结果表明，在卵巢周期期间，脑信号蛋白7A信号在介导成年ME中的周期性神经胶质细胞重塑中发挥作用。 哺乳动物的生殖取决于特定神经元的功能，这些神经元分泌促性腺激素释放激素（GnRH）并将其轴突投射到下丘脑的正中隆起（ME）。在这里，作者表明，Semaphorin 7A信号在介导ME中GnRH轴突终末和伸长细胞的可塑性中起作用。
Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic–pituitary–gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle. Reproduction in mammals is dependent on the function of specific neurons that secrete gonadotropin-releasing hormone (GnRH) and project their axons to the median eminence (ME) of the hypothalamus. Here the authors show that Semaphorin7A signaling plays a role in mediating the plasticity of GnRH axon terminals and tanycytes in the ME.
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影响因子：
9.8
作者：
Giacobini P;Parkash J;Campagne C;Messina A;Casoni F;Vanacker C;Langlet F;Hobo B;Cagnoni G;Gallet S;Hanchate NK;Mazur D;Taniguchi M;Mazzone M;Verhaagen J;Ciofi P;Bouret SG;Tamagnone L;Prevot V
通讯作者：
Prevot V
影响因子：
4.8
作者：
de Seranno, Sandrine;de Tassigny, Xavier d'Anglemont;Prevot, Vincent
通讯作者：
Prevot, Vincent
影响因子：
29
作者：
Balland E;Dam J;Langlet F;Caron E;Steculorum S;Messina A;Rasika S;Falluel-Morel A;Anouar Y;Dehouck B;Trinquet E;Jockers R;Bouret SG;Prévot V
通讯作者：
Prévot V
影响因子：
4.1
作者：
Bouret, S;Prevot, V;Mitchell, V
通讯作者：
Mitchell, V
影响因子：
5.3
作者：
De Seranno, S;Estrella, C;Prevot, V
通讯作者：
Prevot, V