Increased MPO in Colorectal Cancer Is Associated With High Peripheral Neutrophil Counts and a Poor Prognosis: A TCGA With Propensity Score-Matched Analysis.
Increased MPO in Colorectal Cancer Is Associated With High Peripheral Neutrophil Counts and a Poor Prognosis: A TCGA With Propensity Score-Matched Analysis.
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DOI：
10.3389/fonc.2022.940706
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发表时间：
2022
影响因子：
4.7
通讯作者：
Miao, Changhong
中科院分区：
文献类型：
--
作者：
Weng, Meilin;Yue, Ying;Wu, Dan;Zhou, Changming;Guo, Miaomiao;Sun, Caihong;Liao, Qingwu;Sun, Minli;Zhou, Di;Miao, Changhong
关键词：
Myeloperoxidase (MPO) has been demonstrated to be a local mediator of inflammation in tissue damage in various inflammatory diseases. Given its controversial effect on colorectal cancer (CRC), there has been growing interest in investigating the role of this enzyme in CRC. The mechanism underlying MPO activity and CRC progression requires further clarification. The expression and function of MPO in CRC were evaluated using TCGA analysis. TCGA, TIMER, and Human Cell Landscape analyses were used to analyze the correlation between MPO expression and neutrophil infiltration in CRC. Spearman’s bivariate correlation analysis was used to verify the correlation between MPO levels in CRC and the peripheral neutrophil count. In the clinical analysis, 8,121 patients who underwent elective surgery for CRC were enrolled in this retrospective cohort study from January 2008 to December 2014. Propensity score matching was used to address the differences in baseline characteristics. The Kaplan–Meier method and Cox regression analysis were used to identify independent prognostic factors in patients with CRC. MPO was upregulated in CRC tissues, which is related to malignant progression and worse survival in CRC patients from TCGA analysis. MPO was significantly correlated with the infiltration level of neutrophils in CRC in TCGA, TIMER, and Human Cell Landscape analyses. MPO was positively correlated with the peripheral neutrophil count. Data of the 8,121 patients who underwent CRC surgery were available for analysis. After propensity score matching, 3,358 patients were included in each group. Kaplan–Meier survival curves showed that high preoperative neutrophil levels were associated with decreased overall survival (OS; P < 0.001) and disease-free survival (DFS; P = 0.015). The preoperative neutrophil count was an independent risk factor for OS (hazard ratio [HR], 1.157; 95% confidence interval [CI], 1.055–1.268; P = 0.002) and DFS (HR, 1.118; 95% CI, 1.009–1.238; P = 0.033). Our research indicates that increased MPO levels in CRC are significantly correlated with high preoperative neutrophil counts, and both serve as prognostic indicators for worse survival in CRC patients. Our study suggests that neutrophils may be key players in the mechanism linking MPO levels with poor CRC outcomes.
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DOI：
10.1002/cyto.a.23169
发表时间：
2017-08
期刊：
Cytometry. Part A : the journal of the International Society for Analytical Cytology
影响因子：
--
作者：
Masuda S;Shimizu S;Matsuo J;Nishibata Y;Kusunoki Y;Hattanda F;Shida H;Nakazawa D;Tomaru U;Atsumi T;Ishizu A
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影响因子：
10.5
作者：
Brennan CA;Garrett WS
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Garrett WS
影响因子：
5.2
作者：
de Nonneville, Alexandre;Barbolosi, Dominique;Salas, Sebastien
通讯作者：
Salas, Sebastien
影响因子：
7.3
作者：
Martin D;Rödel F;Winkelmann R;Balermpas P;Rödel C;Fokas E
通讯作者：
Fokas E
DOI：
10.1158/1078-0432.ccr-17-1323
发表时间：
2018-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Afghahi A;Purington N;Han SS;Desai M;Pierson E;Mathur MB;Seto T;Thompson CA;Rigdon J;Telli ML;Badve SS;Curtis CN;West RB;Horst K;Gomez SL;Ford JM;Sledge GW;Kurian AW
通讯作者：
Kurian AW