Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactin-releasing factor, salsolinol
Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactin-releasing factor, salsolinol
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DOI：
10.1111/j.0953-8194.2004.01156.x
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发表时间：
2004-03-01
影响因子：
3.2
通讯作者：
Nagy, GM
中科院分区：
文献类型：
--
作者：
Bodn치r, I;Mravec, B;Nagy, GM
催乳素是由脑下垂体的前叶分泌的，以响应吮吸和压力。我们最近观察到，1-甲基-6，7-二羟基-1，2，3，4-四氢异喹啉（salsolinol），产生于垂体的神经中间叶，以及在内侧基底下丘脑，可以选择性地释放催乳素从垂体前叶。因此，有人提出猪毛菜醇是一种假定的内源性催乳素释放因子（PRF）。在这里，我们报告了一种猪毛菜醇的结构类似物，1-甲基-3，4-二氢异喹啉（1 MeDIQ），可以阻断猪毛菜醇诱导的催乳素释放，但不影响促甲状腺激素释放激素（TRH），α-甲基-p-酪氨酸反应的催乳素释放（alphaMpT）（酪氨酸羟化酶抑制剂）、多潘立酮（D-2多巴胺受体拮抗剂）或5-羟色氨酸（5-HTP）（血清素的前体）。1 MeDIQ显著抑制哺乳、固定和福尔马林应激诱导的催乳素释放，而对皮质酮分泌无任何影响。1 MeDIQ诱导的催乳素对固定应激反应的降低具有剂量依赖性。这些结果表明，猪毛菜醇可以发挥关键作用，在调节催乳素释放诱导的生理（哺乳）或环境（压力）刺激。
Prolactin is secreted from the anterior lobe of the pituitary gland in response both to suckling and to stress. We recently observed that 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), produced in the neurointermediate lobe of the pituitary gland, as well as in the medial basal hypothalamus, can selectively release prolactin from the anterior pituitary. Therefore, it has been proposed that salsolinol is a putative endogenous prolactin-releasing factor (PRF). Here, we report that one structural analogue of salsolinol, 1-methyl-3,4-dihydroisoquinoline (1MeDIQ), can block salsolinol-induced release of prolactin, but does not affect prolactin release in response to thyrotropin releasing hormone (TRH), alpha-methyl-p-tyrosine (alphaMpT) (an inhibitor of tyrosine hydroxylase), domperidone (a D-2 dopamine receptor antagonist), or 5-hydroxytryptophan (5-HTP), a precursor of serotonin). 1MeDIQ profoundly inhibited suckling-, immobilization-, as well as formalin-stress induced prolactin release without any influence on corticosterone secretion. The 1MeDIQ-induced reduction in prolactin response to immobilization stress was dose-dependent. These results suggest that salsolinol can play a pivotal role in the regulation of prolactin release induced by either physiological (suckling) or environmental (stress) stimuli.