Cancer and the tumor microenvironment: a review of an essential relationship.
Cancer and the tumor microenvironment: a review of an essential relationship.
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DOI：
10.1007/s00280-008-0881-9
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发表时间：
2009-03
影响因子：
3
通讯作者：
Johann, Donald J., Jr.
中科院分区：
文献类型：
--
作者：
Mbeunkui, Flaubert;Johann, Donald J., Jr.
微环境在癌变的发生和发展过程中的作用现在被认识到是至关重要的，无论是为了加强对基础癌症生物学的理解，还是为了利用这一相对较新的知识来源来改进分子诊断和治疗。本文主要从以下方面进行综述：(1)分泌蛋白的制备和分析方法；(2)肿瘤微环境因子在肿瘤中的作用；(3)肿瘤治疗的潜在分子靶点。肿瘤的微环境是其生理、结构和功能的重要组成部分。它是肿瘤本身的一个重要方面，因为它为恶性过程提供了一个培育环境。肿瘤和间质细胞之间的基本紊乱关系对于肿瘤细胞的生长、进展和危及生命的转移至关重要。提高对这种相互作用的理解可能为癌症管理、风险评估和预防提供新的和有价值的临床靶点。非恶性细胞和来自肿瘤和基质细胞的分泌蛋白是癌症进展的积极参与者。随着肿瘤的进展，通过分子和细胞谱监测肿瘤微环境的变化对于确定癌症预防和治疗的细胞或蛋白质靶点至关重要。
The role of the microenvironment during the initiation and progression of carcinogenesis is now realized to be of critical importance, both for enhanced understanding of fundamental cancer biology, as well as exploiting this source of relatively new knowledge for improved molecular diagnostics and therapeutics. This review focuses on: (1) the approaches of preparing and analyzing secreted proteins, (2) the contribution of tumor microenvironment elements in cancer, and (3) the potential molecular targets for cancer therapy. The microenvironment of a tumor is an integral part of its physiology, structure, and function. It is an essential aspect of the tumor proper, since it supplies a nurturing environment for the malignant process. A fundamental deranged relationship between tumor and stromal cells is essential for tumor cell growth, progression, and development of life threatening metastasis. Improved understanding of this interaction may provide new and valuable clinical targets for cancer management, as well as risk assessment and prevention. Non-malignant cells and secreted proteins from tumor and stromal cells are active participants in cancer progression. Monitoring the change in the tumor micro-environment via molecular and cellular profiles as tumor progresses would be vital for identifying cell or protein targets for cancer prevention and therapy.
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影响因子：
78.5
作者：
Bartlett, JB;Dredge, K;Dalgleish, AG
通讯作者：
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11.2
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通讯作者：
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