The underlying mechanisms of verbal fluency deficit in frontotemporal dementia and semantic dementia
The underlying mechanisms of verbal fluency deficit in frontotemporal dementia and semantic dementia
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DOI：
10.1007/s00415-009-5073-y
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发表时间：
2009-07-01
影响因子：
6
通讯作者：
Desgranges, Beatrice
中科院分区：
文献类型：
--
作者：
Laisney, Mickael;Matuszewski, Vanessa;Desgranges, Beatrice
言语流畅性任务通常用于探索语义记忆和执行功能。本研究的目的是获得一个更好的理解的认知和神经机制的言语流畅性障碍的额叶变异的额颞叶痴呆（fv-FTD）和语义性痴呆（SD）。36例fv-FTD和SD患者和18例老年对照者进行语义和音素流畅性任务。我们还对语义记忆、工作记忆以及转换和更新过程进行了神经心理学研究。我们对流畅性分数和神经心理学数据进行了相关和回归分析。此外，患者接受了静息态正电子发射断层扫描检查，并使用统计参数映射来建立各组患者全脑静息态FDG摄取与流畅性评分之间的相关性。与对照组相比，两个患者组在两个流畅性任务上都表现出受损的表现，但具有不同的模式。虽然fv-FTD患者在语义流畅性方面的得分高于SD患者，但他们在音素任务上的表现没有差异。相关和回归分析清楚地表明，fv-FTD患者在两个流畅性任务上的表现取决于他们的执行能力，而SD患者的表现受到语义记忆存储受损的阻碍。与静息FDG摄取的相关性与认知研究的结果一致。在fv-FTD中，两种流畅性表现都与额叶的代谢有关，而我们观察到SD中两种流畅性任务的表现与左颞叶代谢之间存在显着相关性。
Verbal fluency tasks are commonly used to explore semantic memory and executive functions. The aim of this study was to gain a better understanding of the cognitive and neural mechanisms underlying verbal fluency impairment in the frontal variant of frontotemporal dementia (fv-FTD) and in semantic dementia (SD). Semantic and phonemic fluency tasks were performed by 36 fv-FTD and SD patients and 18 elderly controls. We also carried out a neuropsychological investigation of semantic memory, working memory and shifting and updating processes. We performed correlative and regression analyses of fluency scores and neuropsychological data. In addition, patients underwent a resting positron emission tomography examination, and statistical parametric mapping was used to establish correlations between resting-state FDG uptake in the whole brain and fluency scores for each patient group. Both patient groups displayed impaired performances on both fluency tasks compared with controls, but with different patterns. While fv-FTD patients scored higher than SD patients on semantic fluency, their performances on the phonemic task did not differ. Correlation and regression analyses clearly demonstrated that the fv-FTD patients' performances on both fluency tasks depended on their executive abilities, while those of the SD patients were hampered by the impairment of their semantic memory store. Correlations with resting FDG uptake were consistent with the results of the cognitive study. In fv-FTD, both fluency performances were related to the metabolism of the frontal lobes, while we observed significant correlations between performances on both fluency tasks and the left temporal lobe metabolism in SD.