Antiangiogenic Pterocarpan and Flavonoid Constituents of Erythrina lysistemon.
Antiangiogenic Pterocarpan and Flavonoid Constituents of Erythrina lysistemon.
复制标题
抗血管生成紫檀素和刺桐的类黄酮成分。
DOI：
10.1021/acs.jnatprod.2c00909
复制
发表时间：
2023
影响因子：
5.1
通讯作者：
El-Masry,Sawsan
中科院分区：
文献类型：
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作者：
Nassief,SarahM;Amer,MasoudaE;Shawky,Eman;Sishtla,Kamakshi;Mas-Claret,Eduard;Muniyandi,Anbukkarasi;Corson,TimothyW;Mulholland,DulcieA;El-Masry,Sawsan
生长于埃及的刺桐 (Erythrina lytemon) 的根产生 24 种黄酮类化合物，其中包括 17 种紫檀素、2 种异黄酮、1 种黄烷酮、2 种异黄烷、1 种 2-芳基苯并呋喃和 1 种异黄烷-3-烯。有 9 种紫檀属植物此前未曾报道过（7-9,11-14,19 和 20），其中 11 种是首次报道。使用 HRESIMS、NMR 和圆二色性技术建立结构。测试了所选化合物在体外阻断人视网膜内皮细胞生长的能力和抗血管生成活性。与非内皮细胞类型相比，异黄酮类化合物 5 和 6 以及紫檀素 1、2、4、20 和 22 表现出对内皮细胞的选择性抗增殖活性，并且在体外对 HREC（一种与新生血管性眼病相关的细胞类型）具有浓度依赖性抗血管生成作用。
The roots ofErythrina lysistemon, growing in Egypt, yielded 24 flavonoid compounds, including 17 pterocarpans, two isoflavanones, one flavanone, two isoflavans, one 2-arylbenzofuran, and an isoflava-3-ene. Nine pterocarpans have not been reported previously (7–9,11–14,19, and20), and 11 are reported here for the first time from this species. Structures were established using HRESIMS, NMR, and circular dichroism techniques. Selected compounds were tested for their ability to block the growth of human retinal endothelial cells and antiangiogenic activity in vitro. The isoflavonoids5and6, and the pterocarpans1,2,4,20, and22demonstrated selective antiproliferative activities on endothelial cells compared to a nonendothelial cell type, with concentration-dependent antiangiogenic effects in vitro against HRECs, a cell type relevant to neovascular eye diseases.