Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
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DOI：
10.1126/science.274.5285.262
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发表时间：
1996-10-11
期刊：
影响因子：
56.9
通讯作者：
Fishman, MC
中科院分区：
文献类型：
--
作者：
Mashimo, H;Wu, DC;Fishman, MC
维持胃肠道上皮完整性的机制在很大程度上仍不明确。编码肠三叶因子（ITF）的基因是一种在整个小肠和结肠中分泌的蛋白质，通过靶向破坏使其在小鼠中失去功能。缺乏ITF的小鼠在口服葡聚糖硫酸钠后，粘膜愈合受损，并死于广泛的结肠炎，葡聚糖硫酸钠是一种在野生型小鼠中引起轻度上皮损伤的药物。ITF缺陷型小鼠在损伤后表现出较差的上皮再生。这些发现揭示了ITF在肠粘膜的维持和修复中的核心作用。
The mechanisms that maintain the epithelial integrity of the gastrointestinal tract remain largely undefined. The gene encoding intestinal trefoil factor (ITF), a protein secreted throughout the small intestine and colon, was rendered nonfunctional in mice by targeted disruption. Mice lacking ITF had impaired mucosal healing and died from extensive colitis after oral administration of dextran sulfate sodium, an agent that causes mild epithelial injury in wild-type mice. ITF-deficient mice manifested poor epithelial regeneration after injury. These findings reveal a central role for ITF in the maintenance and repair of the intestinal mucosa.