P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin
P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin
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DOI：
10.4049/jimmunol.169.8.4307
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发表时间：
2002-10-15
影响因子：
4.4
通讯作者：
Furie, B
中科院分区：
文献类型：
--
作者：
Hirata, T;Furie, BC;Furie, B
P- and E-selectin mediate CD4(+) Th1 cell migration into the inflamed skin in a murine contact hypersensitivity model. In this model, not only CD4(+) T cells but also CD8(+) T cells infiltrate the inflamed skin, and the role of CD8(+) type 1 cytotoxic T (Tc1) cells as effector cells has been demonstrated. Here we show that in mice deficient in both P- and E-selectin, the infiltration of CD8(+) T cells in the inflamed skin is reduced, suggesting the role of these selectins in CD8(+) T cell migration. We directly studied the role of selectins using in vitro-generated Tc1 cells. These cells are able to migrate into the inflamed skin of wild-type mice. This migration is partially mediated by P- and E-selectin, as shown by the reduced Tc1 cell migration into the inflamed skin of mice deficient in both P- and E-selectin or wild-type mice treated with the combination of anti-P-selectin and anti-E-selectin Abs. During P- and E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole ligand for P-selectin and one of the ligands for E-selectin. P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly. mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin.
