The effects of imipramine on P50 suppression, prepulse inhibition and habituation of the startle response in humans
The effects of imipramine on P50 suppression, prepulse inhibition and habituation of the startle response in humans
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DOI：
10.1017/s1461145706007504
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发表时间：
2007-12-01
影响因子：
4.8
通讯作者：
Glenthoj, Birte Y.
中科院分区：
文献类型：
--
作者：
Hammer, Trine-Bjoerg;Oranje, Bob;Glenthoj, Birte Y.
精神分裂症患者在感觉信息过滤方面表现出障碍，这可以通过使用声惊反应的脉冲前抑制（PPI）和P50抑制范例来评估。在治疗精神分裂症期间的阴性症状或抑郁综合征时，抗抑郁药通常与抗精神病药物联合使用。然而，抗抑郁药增加单胺能活性，这被认为会减少感觉门控，尽管这些假设主要是基于动物研究的结果。目前，对人类感觉过滤的单胺能调节知之甚少，文献中可以找到的少数报告显示与动物研究存在差异。本研究旨在研究单胺能活性增加对健康志愿者感觉过滤和习惯化的影响。在双盲、安慰剂对照交叉设计中，20名健康男性志愿者接受安慰剂或50mg丙咪嗪（一种双作用抗抑郁药），之后接受P50抑制范式、PPI范式和惊吓反射范式的习惯化测试。丙咪嗪显著降低PPI和P50抑制。两种处理在声惊吓反射的习惯化方面无显著差异。由于精神分裂症患者的感觉过滤通常已经减少，目前的结果要求在广泛使用双作用抗抑郁药治疗这些患者的抑郁或阴性症状时要谨慎。
Schizophrenic patients exhibit impairments in filtering of sensory information, as can be assessed by use of prepulse inhibition (PPI) of the acoustic startle response and P50 suppression paradigms. In the treatment of negative symptoms or depressive syndromes during the course of schizophrenia antidepressants are often combined with antipsychotic medication. However, antidepressants increase monoaminergic activity, which has been suggested to decrease sensory gating, although these presumptions are mostly based on results from animal studies. Currently, little is known about monoaminergic modulation of sensory filtering in humans, and the few reports that can be found in literature show discrepancies with animal studies. The current study was designed to study the effects of increased monoaminergic activity on sensory filtering and habituation of healthy volunteers. In a double-blind, placebo-controlled crossover design, 20 healthy male Volunteers received either placebo or a dose of 50 mg imipramine (a dual-acting antidepressant), after which they were tested in a P50 suppression paradigm, a PPI paradigm, and an habituation of the startle reflex paradigm. Imipramine significantly decreased PPI as well as P50 suppression. No significant differences between the two treatments were observed on habituation of the acoustic startle reflex. Since sensory filtering is usually already reduced in patients with schizophrenia, the current results call for caution in the widespread use of dual-acting antidepressants in the treatment of depressed or negative symptoms in these patients.