Precise Detection of Direct Glomerular Input Duration by the Olfactory Bulb
Precise Detection of Direct Glomerular Input Duration by the Olfactory Bulb
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DOI：
10.1523/jneurosci.3382-14.2014
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发表时间：
2014-11-26
影响因子：
5.3
通讯作者：
Restrepo, Diego
中科院分区：
文献类型：
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作者：
Li, Anan;Gire, David H.;Restrepo, Diego
在嗅觉感觉神经元中表达通道视紫红质-2的小鼠中，蓝光精确地激活向嗅球（OB）的感觉神经元输入不同的持续时间。在行为上，小鼠在直接肾小球激活的持续时间上有10 ms的差异。此外，清醒小鼠OB中的二尖瓣/簇状细胞的子集对刺激持续时间的信息进行了紧张性响应。我们的研究提供的证据表明，持续时间的输入肾小球不同步嗅探检测。这种有效的线索可以用来获得信息的气味羽状物的泡芙。
Sensory neuron input to the olfactory bulb (OB) was activated precisely for different durations with blue light in mice expressing channelrhodopsin-2 in olfactory sensory neurons. Behaviorally the mice discriminated differences of 10 ms in duration of direct glomerular activation. In addition, a subset of mitral/tufted cells in the OB of awake mice responded tonically therefore conveying information on stimulus duration. Our study provides evidence that duration of the input to glomeruli not synchronized to sniffing is detected. This potent cue may be used to obtain information on puffs in odor plumes.