Cocaine addicts with conduct disorder are typified by decreased cortisol responsivity and high plasma levels of DHEA-S.
Cocaine addicts with conduct disorder are typified by decreased cortisol responsivity and high plasma levels of DHEA-S.
复制标题
患有行为障碍的可卡因成瘾者的典型特征是皮质醇反应性降低和血浆 DHEA-S 水平高。
DOI：
10.1159/000079109
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Branchey,Marc
中科院分区：
文献类型：
--
作者：
Buydens-Branchey,Laure;Branchey,Marc
有证据表明，有反社会行为的儿童血浆肾上腺雄激素硫酸脱氢表雄酮(脱氢表雄酮-S)水平升高，另一种肾上腺类固醇皮质醇水平下降，或皮质醇对压力的反应性下降。反社会成年人的皮质醇水平也很低，但他们的脱氢表雄酮-S水平还没有被研究过。本研究旨在对成年可卡因成瘾者同时评估脱氢表雄酮-S和皮质醇作为反社会人格障碍(成人症状)诊断和行为障碍(CD)回顾性诊断的功能。本文测定了40例住院男性患者的基础皮质醇和脱氢表雄酮-S。当患者暴露在压力环境中时，他们的皮质醇反应性也被评估。有回顾性CD诊断的患者在应激时，脱氢表雄酮-S水平显著升高，皮质醇分泌减少。在符合和不符合反社会人格障碍成人标准的患者之间的比较，没有发现在脱氢表雄酮-S或皮质醇反应性方面有任何显著差异。这可能归因于用于定义成人障碍的标准的性质，主要集中在不符合社会规范，而CD的一些标准涉及表现出某种程度的暴力。总而言之，具有CD诊断资格的成年人的脱氢表雄酮-S水平升高，皮质醇反应性降低，这证实了儿童时期的观察结果，并表明儿童时期肾上腺类固醇变化的潜在机制在成年后仍可能发挥作用。
There is evidence that children with antisocial behaviors have increased plasma levels of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) and either a decreased level of another adrenal steroid, cortisol, or a decreased cortisol responsivity to stress. Low levels of cortisol have also been reported in antisocial adults but their levels of DHEA-S have not been studied. The present study was designed to perform in adult cocaine addicts simultaneous assessments of DHEA-S and cortisol as a function of a diagnosis of antisocial personality disorder (adult symptoms) and of a retrospective diagnosis of conduct disorder (CD). Basal cortisol and DHEA-S were determined in the plasma samples of 40 hospitalized men. The patients’ cortisol responsivity was also assessed while they were being exposed to a stressful situation. Patients who had a retrospective CD diagnosis had significantly increased DHEA-S levels and secreted less cortisol when stressed. Comparisons between patients who did and did not meet the antisocial personality disorder adult criteria did not reveal any significant difference in DHEA-S or in cortisol responsivity. This could be attributed to the nature of the criteria used to define the adult disorder, which focus mostly on a failure to conform to social norms, whereas a number of CD criteria involve displays of some degree of violence. In conclusion, adults who retrospectively qualified for a CD diagnosis had increased DHEA-S levels and a decreased cortisol reactivity, confirming observations made in children and indicating that mechanisms underlying adrenal steroid alterations in childhood could still be at play in adulthood.