Do platelets have a role in the pathogenesis of aggressive posterior retinopathy of prematurity?
Do platelets have a role in the pathogenesis of aggressive posterior retinopathy of prematurity?
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DOI：
10.1097/iae.0b013e3181cafc30
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发表时间：
2010-04-01
期刊：
影响因子：
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通讯作者：
Shetty, K Bhujang
中科院分区：
文献类型：
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作者：
Vinekar, Anand;Hegde, Kaushik;Shetty, K Bhujang
目得：本研究的目的是报告血小板减少症在侵袭性早产儿后部视网膜病变（APROP）发病机制中的可能作用。方法：本研究中描述的索引病例显示，在纠正血小板减少症后3天内APROP伴疾病自发消退，不需要激光治疗。回顾性队列研究了9例连续的亚洲印度婴儿，这些婴儿具有相似的分期和疾病作为索引病例。将这些婴儿在激光治疗前的平均血小板计数与21名年龄和出生体重匹配的对照组进行比较。结果：10例APROP患儿平均出生体重1,030 g（± 178 g），平均妊娠29.4周（± 2.0周）。病例组的平均血小板计数为82，870/mm 3（+/-58，702/mm 3），对照组为178，285 +/-57，051/mm 3（P = 0.0002）。10例病例中的5例（50%）和21例对照受试者中的1例（4.8%）的血小板计数为
PURPOSE: The purpose of this study was to report the possible role of thrombocytopenia in the pathogenesis of aggressive posterior retinopathy of prematurity (APROP).METHODS: The index case described in this study showed spontaneous resolution of APROP with plus disease within 3 days of correcting thrombocytopenia and did not require laser treatment. The retrospective cohort of nine consecutive Asian Indian infants with APROP with similar stage and plus disease as the index case was studied. The mean platelet count of these infants before laser treatment was compared with 21 age- and birth weight-matched control subjects. Correlation of platelet count with APROP is discussed.RESULTS: The mean birth weight of the 10 cases with APROP was 1,030 g (+/-178 g), and the mean period of gestation was 29.4 weeks (+/-2.0 weeks). The mean platelet count of the cases was 82,870/mm3 (+/-58,702/mm3) and that of the control subjects was 178,285 +/- 57,051/mm3 (P = 0.0002). Five of the 10 cases (50%) and 1 of the 21 control subjects (4.8%) had a platelet count of