PIWI-like protein 1 upregulation promotes gastric cancer invasion and metastasis
PIWI-like protein 1 upregulation promotes gastric cancer invasion and metastasis
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DOI：
10.2147/ott.s186827
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Gong, Fei
中科院分区：
文献类型：
--
作者：
Gao, Chun-li;Sun, Rui;Gong, Fei
背景资料：PIWI样蛋白1（PIWIL1）是Argonaute蛋白家族的重要成员，与肿瘤细胞的恶性行为密切相关。本研究旨在探讨PIWIL 1与胃癌的关系。方法：检测PIWIL 1在胃癌组织中的表达情况及其与胃癌临床病理特征和预后的关系。结果：PIWIL 1在胃癌组织中表达上调，且与肿瘤分化程度、淋巴结状态和TNM分期相关。PIWIL 1高表达是胃癌患者预后的独立预测因子。结论：PIWIL 1高表达提示胃癌患者预后不良，PIWIL 1可作为预测胃癌患者预后的重要分子标志物。
Background: PIWI-like protein 1 (PIWIL1) is an important member of the Argonaute protein family and is closely related to the malignant behaviors of tumor cells. This study aimed to investigate the relationship between PIWIL1 and gastric cancer (GC).Methods: We investigated PIWIL1 expression status in GC tissues as well as its association with clinicopathological characteristics and prognosis of GC patients. PIWIL1 siRNA was transfected into a GC cell line to elucidate its impact on malignant biological behavior.Results: The results showed that PIWIL1 was upregulated in GC tissues and correlated with tumor differentiation, lymph node status, and TNM stage. The high PIWIL1 expression was an independent predictor for the prognosis of patients with GC. Silencing of PIWIL1 expression in GC cell lines suppressed tumor cell proliferation, migration, and invasion.Conclusion: High PIWIL1 expression suggests a poor prognosis for GC patients and PIWIL1 can serve as an important molecular marker for predicting the prognosis of GC patients.