Metal-Free Enantioselective Hydroxyamination of Aldehydes with Nitrosocarbonyl Compounds Catalyzed by an Axially Chiral Amine
Metal-Free Enantioselective Hydroxyamination of Aldehydes with Nitrosocarbonyl Compounds Catalyzed by an Axially Chiral Amine
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DOI：
10.1021/ja4099627
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发表时间：
2013-12-04
影响因子：
15
通讯作者：
Maruoka, Keiji
中科院分区：
文献类型：
--
作者：
Kano, Taichi;Shirozu, Fumitaka;Maruoka, Keiji
通过在联萘基改性的胺催化剂的存在下组合使用克里思和BPO作为氧化剂，实现了醛与来自异羟肟酸衍生物的原位生成的亚硝基羰基化合物的高度区域选择性和对映选择性羟胺化的第一个实例。
The first example of a highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from hydroxamic acid derivatives was realized by combined use of TEMPO and BPO as the oxidant in the presence of a binaphthyl-modified amine catalyst.