Sexual Dimorphism in Adipose-Hypothalamic Crosstalk and the Contribution of Aryl Hydrocarbon Receptor to Regulate Energy Homeostasis.
Sexual Dimorphism in Adipose-Hypothalamic Crosstalk and the Contribution of Aryl Hydrocarbon Receptor to Regulate Energy Homeostasis.
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脂肪-下丘脑串扰中的性二态性和芳香烃受体在调节能量稳态中的作用
DOI：
10.3390/ijms23147679
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发表时间：
2022-07-12
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在能量平衡的调节方面存在着根本的性别差异。更好地理解能量平衡的潜在机制，解释这种不对称将有助于开发性别特异性治疗性二型性疾病，如肥胖症。包括下丘脑和脂肪组织在内的多个器官在调节能量稳态方面起着至关重要的作用，这在男性和女性中受到不同的调节。各种神经元群体，特别是下丘脑内的神经元群体，如弓状核（ARC），可以通过外周激素如来自脂肪细胞的瘦素的帮助来感知身体的营养成分，以调节能量稳态。这篇综述总结了脂肪组织如何与大脑中的稳态网络控制系统，其中包括能量调节区域和下丘脑-垂体轴，串扰有助于在性别特异性的方式进行能量调节。此外，肥胖的发展取决于饮食和环境因素。来自饮食和环境污染物的物质可通过芳香烃受体（AhR）对能量代谢产生潜在影响。发育性AhR激活可以赋予神经元发育的永久性改变，可以表现出许多性别特异性的生理变化，有时仅在成年期变得明显。AhR目前正在研究作为治疗肥胖的潜在靶点。人们的共识是，受体功能受损可以保护小鼠免于肥胖。AhR也调节性类固醇受体，因此，本次审查的目标之一是解释为什么调查性别差异，同时检查这种受体是至关重要的。总体而言，本次审查总结了脂肪-下丘脑轴赋予的能量稳态调节的性别差异，并研究了该轴如何受到异生物质通过AhR信号的影响。
There are fundamental sex differences in the regulation of energy homeostasis. Better understanding of the underlying mechanisms of energy balance that account for this asymmetry will assist in developing sex-specific therapies for sexually dimorphic diseases such as obesity. Multiple organs, including the hypothalamus and adipose tissue, play vital roles in the regulation of energy homeostasis, which are regulated differently in males and females. Various neuronal populations, particularly within the hypothalamus, such as arcuate nucleus (ARC), can sense nutrient content of the body by the help of peripheral hormones such leptin, derived from adipocytes, to regulate energy homeostasis. This review summarizes how adipose tissue crosstalk with homeostatic network control systems in the brain, which includes energy regulatory regions and the hypothalamic–pituitary axis, contribute to energy regulation in a sex-specific manner. Moreover, development of obesity is contingent upon diet and environmental factors. Substances from diet and environmental contaminants can exert insidious effects on energy metabolism, acting peripherally through the aryl hydrocarbon receptor (AhR). Developmental AhR activation can impart permanent alterations of neuronal development that can manifest a number of sex-specific physiological changes, which sometimes become evident only in adulthood. AhR is currently being investigated as a potential target for treating obesity. The consensus is that impaired function of the receptor protects from obesity in mice. AhR also modulates sex steroid receptors, and hence, one of the objectives of this review is to explain why investigating sex differences while examining this receptor is crucial. Overall, this review summarizes sex differences in the regulation of energy homeostasis imparted by the adipose–hypothalamic axis and examines how this axis can be affected by xenobiotics that signal through AhR.
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影响因子：
10.4
作者：
Baker NA;Shoemaker R;English V;Larian N;Sunkara M;Morris AJ;Walker M;Yiannikouris F;Cassis LA
通讯作者：
Cassis LA
影响因子：
4.8
作者：
Alexanderson, Camilla;Eriksson, Elias;Holmaeng, Agneta
通讯作者：
Holmaeng, Agneta
影响因子：
2.9
作者：
Adam, Tanja C.;Epel, Elissa S.
通讯作者：
Epel, Elissa S.
影响因子：
5.8
作者：
Ballesteros, M;Leung, KC;Ho, KKY
通讯作者：
Ho, KKY
影响因子：
4.5
作者：
Abbott, BD
通讯作者：
Abbott, BD