Synthesis of angiotensinogen by isolated rat liver cells and its regulation in comparison to serum albumin.
Synthesis of angiotensinogen by isolated rat liver cells and its regulation in comparison to serum albumin.
复制标题
离体大鼠肝细胞合成血管紧张素原及其与血清白蛋白相比的调节。
DOI：
10.1016/0006-291x(77)91295-5
复制
发表时间：
1977
影响因子：
3.1
通讯作者：
C. Falge
中科院分区：
文献类型：
--
作者：
K. Weigand;H. Warnze;C. Falge
Angiotensinogen (renin substrate) and albumin are synthesized by isolated hepatocytes almost linearly for 5 hr. The incorporation of radioactive leucine into total protein proceeded linearly for 3 hr. Without addition of amino acids to the incubation medium the synthesis of both proteins was still linear but fell off to 40% compared to the synthesis rate obtained by incubation with amino acids in serum concentrations. Higher amino acid concentrations could not further stimulate the synthesis. Addition or withdrawal of tryptophan had no effect on the synthesis rate of both proteins. After 5 hr incubation hydrocortisone had stimulated the incorporation of radioactive leucine into total protein by 13%, the albumin synthesis by 43%, and the angiotensinogen synthesis by 142%.
