HEMOSTATIC FUNCTION AND PLATELET POLY-UNSATURATED FATTY-ACIDS IN ESKIMOS
HEMOSTATIC FUNCTION AND PLATELET POLY-UNSATURATED FATTY-ACIDS IN ESKIMOS
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DOI：
10.1016/s0140-6736(79)91490-9
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发表时间：
1979-01-01
期刊：
影响因子：
168.9
通讯作者：
BANG, HO
中科院分区：
文献类型：
--
作者：
DYERBERG, J;BANG, HO
爱斯基摩人死于心血管疾病的情况很少见。对 21 名格陵兰爱斯基摩人和 21 名年龄和性别匹配的丹麦对照组进行了止血研究。血小板脂质分析表明，爱斯基摩人大量摄入omega-3多不饱和脂肪酸（例如顺式5、8、11、14、17-二十碳五烯酸[C20:5]）会增加血小板中omega-3多不饱和脂肪酸的比例。由于血小板聚集减少，爱斯基摩人的出血时间明显更长。血小板中的 C20:5 可能被血管内皮转化为抗聚集的前列环素。用二十碳五烯酸部分替代花生四烯酸可以降低血栓性疾病（包括心肌梗塞）的发生率。
Death from cardiovascular disease is rare among Eskimos. Hemostasis was investigated in 21 Greenland Eskimos and 21 age and sex matched Danish controls. Platelet lipid analysis demonstrated that a high consumption of .omega.-3 polyunsaturated fatty acids (such as cis 5, 8, 11, 14, 17-eicosapentaenoic acid [C20:5]) by Eskimos increased the proportion of .omega.-3 polyunsaturated fatty acids in the platelets. The Eskimos had a significantly longer bleeding-time due to reduced platelet aggregation. C20:5 in the platelets may be converted by the vascular endothelium to anti-aggregatory prostacyclin. Partial dietary substitution of arachidonic acid by eicosapentaenoic acid may reduce the incidence of thrombotic disorders, including myocardial infarction.